71028-76-7Relevant academic research and scientific papers
A three-enzyme system involving an ene-reductase for generating valuable chiral building blocks
Mangan, David,Miskelly, Iain,Moody, Thomas S.
, p. 2185 - 2190,6 (2020/09/02)
The use of ene-reductase (ERED) enzymes for the asymmetric reduction of olefins offers a green, renewable alternative to metal-catalysed asymmetric reduction. We report herein the first example of an ERED-catalysed enantiospecific reduction carried out at large scale using a carbonyl reductase (CRED) enzyme in the cofactor recycle. This reaction has been paired with a hydrolase-mediated regioselective ester hydrolysis to generate a valuable chiral building block using a straightforward one-pot process. Copyright
