710309-78-7Relevant academic research and scientific papers
Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents
Zheng, Qing-Zhong,Cheng, Kui,Zhang, Xiao-Min,Liu, Kai,Jiao, Qing-Cai,Zhu, Hai-Liang
, p. 3207 - 3212 (2010)
A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi.
