71032-69-4Relevant academic research and scientific papers
Synthesis of Azaspiro Ketones via Ring Contraction of Heterocyclic Enamino Esters
Duhamel, Pierre,Kotera, Mitsuharu
, p. 1688 - 1691 (1982)
Upon treatment by bromine followed by water-triethylamine, six- and seven-membered heterocyclic enamino esters 4a,b underwent easily ring contraction, giving five- and six-membered azacyclic aldehydes 5a,b, respectively.The resulted aldehydes 5 were converted to azaspiro ketones 8a,b in three steps.Starting 3-substituted seven-membered heterocyclic enamino ester 4a was synthesized by desulfurization of ketene acetal 12 with Raney nickel. 3-(Methoxycarbonyl)-N-methylcaprolactam, prepared from N-methylcaprolactam , was converted to the corresponding thio lactam by treatment with P2S5 in CS2, which upon reaction with CH3I followed by deprotonation with NEt3 afforded the ketene acetal 12.
Spiro-compound, and preparation method and application thereof
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, (2017/02/17)
The invention relates to the fields of medicinal chemistry and pharmacotherapeutics, and discloses a spiro-compound as shown in the following general formula, and a preparation method and application thereof. A bioactivity screening result shows that the
