710322-57-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyrazinecarboxylic acid, 5-formyl-, methyl ester (9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its potential applications in medicine. Its unique chemical structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, Pyrazinecarboxylic acid, 5-formyl-, methyl ester (9CI) serves as an essential intermediate in the production of agrochemicals. Its role in the synthesis of various agrochemicals contributes to the development of effective pesticides and other agricultural products to enhance crop protection and yield.

Upstream product

• 710322-24-0 5-(2-dimethylamino-vinyl)-pyrazine-2-carboxylic acid methyl ester 
• 41110-33-2 5-methylpyrazine-2-carboxylic acid methyl ester 
• 64-17-5 ethanol 
• 866327-72-2 5-dibromomethyl-pyrazine-2-carboxylic acid methyl ester 

Downstream Products

• 1388149-45-8 C₂₄H₂₄F₅N₅O₄S 
• 1388149-44-7 N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide 
• 1262803-64-4 methyl 5-(hydroxymethyl)pyrazine-2-carboxylate 

Relevant academic research and scientific papers

Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists

A series of small molecules consisting of a heterocyclic core flanked by two basic functionalities were synthesized and screened for in vitro affinity at the human histamine H3 receptor (hH3R). Nine of the twenty-eight compounds tested were found to possess a hH3R Ki of less than 5 nM and consisted of a diverse range of central hetero-aromatic linkers (pyridine, pyrazine, oxazole, isoxazole, thiazole, furan, thiophene, and pyrrole). One member of this series, (4-isopropyl-piperazin-1-yl)-(6-piperidin-1-ylmethyl-pyridin-3-yl)-methanone (37), was found to be a high affinity, selective antagonist that crosses the blood-brain barrier and occupies H3 receptors after oral administration in the rat.

Non-Imidazole heterocyclic compounds

Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.

5-SUBSTITUTED-PYRAZINE OR PYRIDINE GLUCOKINASE ACTIVATORS

The present invention provides a compound according to formula (I) where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula (I) are also provided, said compounds being glucokinase activators which are useful in the treatment of type II diabetes.