71035-26-2

Upstream product

• 110-91-8 morpholine 
• 22959-34-8 1-(4-chlorophenyl)-2-propyn-1-one 
• 19578-13-3 1-(p-Chlorophenyl)-3-(4'-morpholinyl)-1-propanone 
• 67382-35-8 (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one 
• 13856-85-4 1-(4-chlorophenyl)-1-propanol 
• 67228-76-6 4-chlorophenylpropynal 
• 29805-11-6 1-(4-chlorophenyl)prop-2-yn-1-ol 

Downstream Products

• 16254-20-9 1-(4-chlorophenyl)-3-morpholinopropan-1-ol 

Relevant academic research and scientific papers

Silver-catalyzed efficient synthesis of enaminones from propargyl alcohols and amines

Enaminones are used as the key intermediates to construct heterocyclic compounds with various bioactivities. In this study, a simple and efficient approach for the synthesis of enaminones via amination of propargyl alcohols was developed. Under the catalysis of Ag2CO3, the reaction proceeded smoothly to afford the desired products in good yields. Preliminary mechanism experiments showed that Ag2CO3 played an essential role in the procedure of the reaction.

Tunable and Diastereoselective Br?nsted Acid Catalyzed Synthesis of β-Enaminones

The Br?nsted acid catalyzed Meyer-Schuster reaction of hemiaminals was studied for the stereoselective synthesis of β-enaminones. Hemiaminals were formed from propargyl aldehydes (or the oxidation of propargyl alcohols) and amines in the presence of Br?ns

Transformation of α-substituted propanols into γ-amino alcohols through nickel-catalyzed amination on the terminal γ-carbon of propanols

A nickel-phosphine complex was found to be effective as the catalyst for the transformation of alcohols into β-enaminones, which was successively converted into γ-amino alcohols by a conventional reductant. The sequential transformation is equivalent to the carbon-nitrogen bond formation at the γ-position of saturated alcohols. Georg Thieme Verlag Stuttgart · New York.

Studies with Enaminones: The reaction of enaminones with Aminoheterocycles. A route to Azolopyrimidines, Azolopyridines and Quinolines

The enaminones 1b,d,f react with 4-phenyl-3-methyl-5-pyrazoleamine 3a to yield the pyrazole derivatives 4a-c that cyclised readily on reflux in pyridine solution in presence of hydrochloric acid to yield the pyrazolo[1,5-a]pyrimidines 5a-c. Similarly 3(5)

The influence of substituents on the photochemical generation and stability of 2-morpholinocyclopropanols

By irradiation in oxygen-free ether α- or β-substituted β-morpholinopropiophenones 1a-c form the corresponding cyclopropanols 2 with 1-aryl and 2-morpholino group in a relative cis-configuration in high yields. The photocyclization of pure 1a-c enantiomer