710355-23-0Relevant academic research and scientific papers
Microwave-assisted solvent-free intramolecular 1,3-dipolar cycloaddition reactions leading to hexahydrochromeno[4,3-b]pyrroles: scope and limitations
Pospí?il, Ji?í,Potá?ek, Milan
, p. 337 - 346 (2007)
We report the microwave-assisted solvent-free synthesis of hexahydrochromeno[4,3-b]pyrroles. Intramolecular 1,3-dipolar cycloadditions proceed under these conditions within 15-40 min in 16-84% yields. An influence of the microwave irradiation upon various [3+2] cycloaddition reaction intermediates was studied. Additionally, a scope and limitations of these reactions including an influence of the dipolarophile geometry upon the cycloaddition selectivity and steric demands of the dipole upon its reactivity were also disclosed. These observations led us to postulate a preferable transition state of the reaction. Finally, an influence of the microwave irradiation to the isomerization of activated olefins was also described.
A solvent-free method for substituted imidazolidin-4-ones synthesis
Pospí?il, Ji?í,Potá?ek, Milan
, p. 1165 - 1173 (2007/10/03)
A new method of the solvent-free synthesis of substituted imidazolidin-4-ones is described. The method is developed for microwave-assisted solvent-free conditions and compared with classical thermally initiated solvent-free conditions. In both cases the reaction proceeds with good yields. However, the reaction under microwave conditions is accelerated six-times. Thermal effect of the microwaves is observed.
