71039-74-2

Upstream product

• 125379-87-5 Benzoic acid 4-(4-carboxy-butyrylamino)-phenyl ester 
• 108-55-4 glutaric anhydride, 
• 123-30-8 4-amino-phenol 

Relevant academic research and scientific papers

Composition and method for dyeing dye-susceptible material

Composition for colouring dye-susceptible material (preferably keratinous material), containing at least one pro-dye (especially a glutaramide) and at least one enzyme capable of reacting, cleaving, or modifying the enzymatically-labile functionality in the pro-dye to form a dye substance or a direct dye; as well as a 2-component-kit.

Symmetric, monofunctionalised polymethine dyes labelling reagents

A symmetric cyanine of the formula: wherein:X is selected from the group consisting of O, S and C(CH3)2;W represents non-metal atoms required to form a benzo-condensed or a naphto-condensed ring;R1 is selected from the group consisting of (CH2)nCH3, (CH2)nSO3- and (CH2)nSO3H, wherein n is an integer selected from 0 to 6 when R1 is (CH2)nCH3, and n is an integer selected from 3 to 6 when R1 is (CH2)nSO3- or (CH2)nSO3H;R2 and R3 are independently selected from the group consisting of H, a sulphonic moiety and a sulphonate moiety;Q is selected from the group consisting of:wherein q is 0 or 1 and D is selected from the group consisting of:-C≡C-G; andwherein A is O or S and G is, or contains a N, O or S nucleophile moiety or is, or contains a moiety capable of reacting with N, O or S nucleophiles.

Symmetric, monofunctionalised polymethine dyes labelling reagents

A symmetric cyanine of the formula: wherein:X is selected from the group consisting of O, S and C(CH3)2;W represents non-metal atoms required to form a benzo-condensed or a naphto-condensed ring;R1 is selected from the gro

Catalytic antibodies induced by a zwitterionic hapten

A zwitterionic hapten 4 featuring both positively and negatively charged functional groups was designed and synthesized with the goal of generating catalytic antibodies for the hydrolysis of ester 6 and amide 7. Of the 36 monoclonal antibodies specific to BSA-4 (bovine serum albumin) that were isolated, six accelerated the hydrolysis of 6. Two catalytic antibodies with distinctively different and representative kinetic behaviors were selected for detailed kinetic studies. Whereas H8-2-6F11 showed burst kinetic behavior, which can be attributed to the formation of an acyl intermediate, H8-1-2D5 did not, but it did exhibit high multiple turnover activity. The rate of hydrolysis of 6 catalyzed by H8-1-2D5 followed Michaelis-Menten kinetics; the apparent values of the Michaelis-Menten constant Km and the catalytic constant kcat were 488 μM and 3.5 min-1 respectively. The catalytic rate enhancement (kcat/kun) observed for H8-1-2D5 was 1.3 × 105, which is approximately two orders of magnitude greater than those for monofunctional haptens. Thus H8-1-2D5 compares well in catalytic activity with antibodies isolated by a related approach called heterologous immunization.