71057-08-4Relevant academic research and scientific papers
Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Pupo, Gabriele,Vicini, Anna Chiara,Ascough, David M. H.,Ibba, Francesco,Christensen, Kirsten E.,Thompson, Amber L.,Brown, John M.,Paton, Robert S.,Gouverneur, Véronique
supporting information, p. 2878 - 2883 (2019/02/14)
Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle and low-cost. However, poor solubility in organic solvents coupled with limited strategies to control its reactivity has discouraged its use for asymmetric C-F
Chiral monofluorobenzyl carbanions: Synthesis of enantiopure β-fluorinated β-phenylethylamines
Garcia Ruano, Jose L.,Parra, Alejandro,Alonso, Ines,Fustero, Santos,Del Pozo, Carlos,Arroyo, Yolanda,Sanz-Tejedor, Ascension
experimental part, p. 6142 - 6147 (2011/06/24)
The preparation of a stabilized monofluorobenzyl carbanion by means of a remote homochiral sulfinyl group and its completely stereoselective reactions with N-p-tolylsulfinylimines are described. The use of these reactions followed by the simultaneous remo
SELECTIVE REDUCTION OF β-FLUOROAZIDES TO β-FLUOROAMINES
Hamman, S.,Beguin, C.G.
, p. 191 - 196 (2007/10/02)
Three methods were tested to reduce chemoselectively β-fluoroazides into β-fluoroamines : catalytic hydrogenation, catalytic transfer hydrogenation, and reduction with triphenyl phosphine.The last was the best.
Ring Opening of Aziridines by Different Fluorinating Reagents: Three Synthetic Routes to α,β-Fluoro Amines with Different Stereochemical Pathways
Alvernhe, Gerald M.,Ennakoua, Christine M.,Lacombe, Sylvie M.,Laurent, Andre J.
, p. 4938 - 4948 (2007/10/02)
The syntheses of α,β-fluoro amines from the reaction of secondary aziridines with either Olah's reagent (HF, pyridine) or anhydrous hydrogen fluoride and of N-activated aziridines with partially neutralized Olah's reagent (NR3-nHF) are reported.The stereo
Preparation of Fluoro Amines by the Reaction of Aziridines with Hydrogen Fluoride in Pyridine Solution
Wade, Tamsir N.
, p. 5328 - 5333 (2007/10/02)
Hydrogen fluoride combines regiospecifically with aziridines (1) to give 2-fluoro amines (6) in good yields.Fluorine attack is in all cases completely directed to the most substituted ring carbon or to the benzylic carbon.The results, for benzylic aziridi
