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7107-10-0

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7107-10-0 Usage

Synthesis Reference(s)

Canadian Journal of Chemistry, 44, p. 1875, 1966 DOI: 10.1139/v66-283

Check Digit Verification of cas no

The CAS Registry Mumber 7107-10-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,0 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7107-10:
(6*7)+(5*1)+(4*0)+(3*7)+(2*1)+(1*0)=70
70 % 10 = 0
So 7107-10-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H5NO5/c9-5-2-7-6(12-3-13-7)1-4(5)8(10)11/h1-2,9H,3H2

7107-10-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-nitro-1,3-benzodioxol-5-ol

1.2 Other means of identification

Product number -
Other names 3,4-methylenedioxy 6-nitrophenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7107-10-0 SDS

7107-10-0Relevant articles and documents

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Brogi, Simone,Ramunno, Anna,Savi, Lida,Chemi, Giulia,Alfano, Gloria,Pecorelli, Alessandra,Pambianchi, Erika,Galatello, Paola,Compagnoni, Giulia,Focher, Federico,Biamonti, Giuseppe,Valacchi, Giuseppe,Butini, Stefania,Gemma, Sandra,Campiani, Giuseppe,Brindisi, Margherita

, p. 438 - 457 (2017/07/10)

The manuscript deals with the design, synthesis and biological evaluation of novel benzoxazinone-based and indole-based compounds as multifunctional neuroprotective agents. These compounds inhibit human adenosine kinase (hAK) and human glycogen synthase kinase 3 beta (hGSK-3β) enzymes. Computational analysis based on a molecular docking approach underlined the potential structural requirements for simultaneously targeting both proteins’ allosteric sites. In silico hints drove the synthesis of appropriately decorated benzoxazinones and indoles (5a-s, and 6a-c) and biochemical analysis revealed their behavior as allosteric inhibitors of hGSK-3β. For both our hit 4 and the best compounds of the series (5c,l and 6b) the potential antioxidant profile was assessed in human neuroblastoma cell lines (IMR 32, undifferentiated and neuronal differentiated), by evaluating the protective effect of selected compounds against H2O2 cytotoxicity and reactive oxygen species (ROS) production. Results showed a strong efficacy of the tested compounds, even at the lower doses, in counteracting the induced oxidative stress (50 μM of H2O2) and in preventing ROS formation. In addition, the tested compounds did not show any cytotoxic effect determined by the LDH release, at the concentration range analyzed (from 0.1 to 50 μM). This study allowed the identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date. Compound 5l, which behaves as an effective antioxidant, holds promise for the development of new series of potential therapeutic agents for the treatment of neurodegenerative diseases characterized by an innovative pharmacological profile.

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