71079-85-1Relevant academic research and scientific papers
Basic Antiinflammatory Compounds. N,N',N''-Trisubstituted Guanidines
Rachlin, Schneur,Bramm, E.,Ahnfelt-Ronne, I.,Arrigoni-Martelli, E.
, p. 13 - 20 (2007/10/02)
A variety of basic N,N',N''-trisubstituted guanidines was prepared and tested for antiinflammatory activity.Compounds with a thiazoylguanidine moiety linked to the 4 position of the 2-methylquinoline ring exhibited fairly high antiinflammatory activity.Optimal activity was associated with the presence of N-cycloalkyl substituents on N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine.Pharmalogical data on N-cyclohexyl-N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine (SR 1368, 44) are presented and discussed.
