71082-99-0

Basic information

• Product Name: 8-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID
• Synonyms: ASISCHEM D48884;8-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID;OTAVA-BB BB7018670068;8-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
• CAS NO: 71082-99-0
• Molecular Formula: C10H6FNO3
• Molecular Weight: 207.16
• Mol File: 71082-99-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID(71082-99-0)
• EPA Substance Registry System: 8-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID(71082-99-0)

Safety Data

• Hazardous Substances Data: 71082-99-0(Hazardous Substances Data)

Usage

General Description

8-Fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid is a chemical compound with the molecular formula C11H7FNO3. It is a fluoroquinolone antibiotic, primarily used as a broad-spectrum antibiotic against a variety of bacterial infections. The compound works by inhibiting the DNA gyrase and topoisomerase IV enzymes, preventing DNA replication and transcription in bacteria, ultimately leading to their death. It is commonly used to treat urinary tract infections, respiratory infections, skin infections, and other bacterial-related illnesses. However, due to its potential adverse effects and the emergence of bacterial resistance, its use is being increasingly restricted and reserved for severe or resistant infections.

Upstream product

• 71083-06-2 ethyl 8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 348-54-9 2-Fluoroaniline 
• 63010-68-4 diethyl [(2-fluoroanilino)methylidene]malonate 

Relevant articles and documents

Polysubstituted quinolone compounds, and preparation method and use thereof

The invention provides polysubstituted quinolone compounds, and a preparation method and a use thereof, and concretely provides a polysubstituted quinolone compound represented by formula I, and optical isomers, pharmaceutically acceptable salts or solvates thereof. All groups in the formula I are defined in the description. The quinolone compound has excellent c-Met inhibition activity, and can be used for treating c-Met activity or expression level corrected diseases.

Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2

Due to the emerging role of protein kinase CK2 as a molecule that participates not only in the development of some cancers but also in viral infections and inflammatory failures, small organic inhibitors of CK2, besides application in scientific research, may have therapeutic significance. In this paper, we present a new class of CK2 inhibitors-3-carboxy-4(1H)-quinolones. This class of inhibitors has been selected via receptor-based virtual screening of the Otava compound library. It was revealed that the most active compounds, 5,6,8-trichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) (IC 50 = 0.3 μM) and 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid (9) (IC50 = 1 μM), are ATP competitive (Ki values are 0.06 and 0.28 μM, respectively). Evaluation of the inhibitors on seven protein kinases shows considerable selectivity toward CK2. According to theoretical calculations and experimental data, a structural model describing the key features of 3-carboxy-4(1H)-quinolones responsible for tight binding to CK2 active site has been developed.