71083-10-8 Usage
Uses
Used in Pharmaceutical Research and Development:
4-Hydroxy-5,8-dimethylquinoline-3-carboxylic acid ethyl ester is used as a research compound for its potential antimalarial and antitumor properties. Its biological activities, such as inhibitory effects on cell growth, make it a promising candidate for further investigation and development as a potential therapeutic agent.
Used in Antimalarial Applications:
In the field of antimalarial research, 4-Hydroxy-5,8-dimethylquinoline-3-carboxylic acid ethyl ester is used as a potential therapeutic agent for the treatment of malaria. Its quinoline structure and biological activities suggest that it may have the ability to target and inhibit the growth of Plasmodium parasites, which cause malaria.
Used in Antitumor Applications:
In the field of antitumor research, 4-Hydroxy-5,8-dimethylquinoline-3-carboxylic acid ethyl ester is used as a potential therapeutic agent for the treatment of cancer. Its inhibitory effects on cell growth and potential to target cancer cells make it a promising candidate for further investigation and development as a potential anticancer drug.
Check Digit Verification of cas no
The CAS Registry Mumber 71083-10-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,0,8 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 71083-10:
(7*7)+(6*1)+(5*0)+(4*8)+(3*3)+(2*1)+(1*0)=98
98 % 10 = 8
So 71083-10-8 is a valid CAS Registry Number.
71083-10-8Relevant academic research and scientific papers
Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2
Golub, Andriy G.,Yakovenko, Olexander Ya.,Bdzhola, Volodymyr G.,Sapelkin, Vladislav M.,Zien, Piotr,Yarmoluk, Sergiy M.
, p. 6443 - 6450 (2007/10/03)
Due to the emerging role of protein kinase CK2 as a molecule that participates not only in the development of some cancers but also in viral infections and inflammatory failures, small organic inhibitors of CK2, besides application in scientific research, may have therapeutic significance. In this paper, we present a new class of CK2 inhibitors-3-carboxy-4(1H)-quinolones. This class of inhibitors has been selected via receptor-based virtual screening of the Otava compound library. It was revealed that the most active compounds, 5,6,8-trichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) (IC 50 = 0.3 μM) and 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid (9) (IC50 = 1 μM), are ATP competitive (Ki values are 0.06 and 0.28 μM, respectively). Evaluation of the inhibitors on seven protein kinases shows considerable selectivity toward CK2. According to theoretical calculations and experimental data, a structural model describing the key features of 3-carboxy-4(1H)-quinolones responsible for tight binding to CK2 active site has been developed.
