71083-64-2

Basic information

• Product Name: 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• Synonyms: 4-Hydroxy-7-methoxychinolin-3-carbonitril; 4-hydroxy-7-methoxyquinoline-3-carbonitrile; 7-Methoxy-4-oxo-1,4-dihydrochinolin-3-carbonitril
• CAS NO: 71083-64-2
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.1934
• Mol File: 71083-64-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 352.3°C at 760 mmHg
• Flash Point: 166.8°C
• Density: 1.32g/cm³
• Vapor Pressure: 3.88E-05mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile(71083-64-2)
• EPA Substance Registry System: 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile(71083-64-2)

Safety Data

• Hazardous Substances Data: 71083-64-2(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 2458-25-5 ethyl 2-cyano-3-((3-methoxyphenyl)amino)acrylate 
• 104-94-9 4-methoxy-aniline 
• 94-05-3 2-cyano-3-ethoxyacrylic acid ethyl ester 
• 50413-30-4 methyl 2-amino-4-methoxybenzoate 
• 20428-58-4 α-lithioacetonitrile 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 101-84-8 diphenylether 

Downstream Products

• 73387-74-3 4-chloro-7-methoxy-quinoline-3-carbonitrile 
• 214470-27-6 1,4-dihydro-7-methoxy-6-nitro-4-oxo-quinoline-3-carbonitrile 
• 214485-59-3 4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214485-60-6 6-amino-4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinoline-3-carbonitrile 
• 214484-01-2 4-[(3-bromophenyl)amino]-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214484-03-4 6-amino-4-[(3-bromophenyl)amino]-7-methoxy-quinoline-3-carbonitrile 
• 214470-33-4 4-chloro-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214485-38-8 N-{4-[(3-bromo-4-fluorophenyl)amino]-3-cyano-7-methoxy-6-quinolinyl}-4-morpholino-2-butenamide 
• 214485-63-9 4-morpholin-4-yl-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide 
• 214485-58-2 4-morpholin-4-yl-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide 
• 214485-62-8 4-diethylamino-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide 
• 214485-57-1 4-diethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide 
• 214485-66-2 4-dimethylamino-but-2-enoic acid [4-(3-bromo-4-fluorophenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide 
• 214485-56-0 4-dimethylamino-but-2-enoic acid [4-(3-brom-phenylamino)-3-cyano-7-methoxy-quinolin-6yl]-amide 

Relevant articles and documents

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor

Fused pyrimidinone and quinolone derivatives that are of potential interest to pharmaceutical research were synthesized within minutes in up to 96% yield in an automated Phoenix high-temperature and high-pressure continuous flow reactor. Heterocyclic scaffolds that are either hard to synthesize or require multisteps are readily accessible using a common set of reaction conditions. The use of low-boiling solvents along with the high conversions of these reactions allowed for facile workup and isolation. The methods reported herein are highly amenable for fast and efficient heterocycle synthesis as well as compound scale-ups.

ANTIVIRAL AGENTS

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TRICYCLIC PROTEIN KINASE INHIBITORS

This invention provides compounds of Formula (I), where A'', Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.