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71083-78-8

4-Hydroxy-5,8-dimethoxyquinoline-3-carbonitrile is a complex organic compound with the molecular formula C13H10N2O3. It is characterized by a quinoline ring structure, which is a tricyclic system consisting of a benzene ring fused to a pyridine ring. The compound features a hydroxyl group (-OH) at the 4-position, two methoxy groups (-OCH3) at the 5 and 8 positions, and a nitrile group (-CN) at the 3-position. This chemical is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as an intermediate in the production of certain quinoline-based compounds. Its unique structure and functional groups make it a subject of interest in the field of organic chemistry and drug development.

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  • 71083-78-8 Structure

  • Basic information

    1. Product Name: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile
    2. Synonyms: 4-Hydroxy-5,8-dimethoxychinolin-3-carbonitril; 5,8-Dimethoxy-4-oxo-1,4-dihydrochinolin-3-carbonitril; 5,8-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile
    3. CAS NO:71083-78-8
    4. Molecular Formula: C12H10N2O3
    5. Molecular Weight: 230.2194
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 71083-78-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 461.4°C at 760 mmHg
    3. Flash Point: 232.9°C
    4. Appearance: N/A
    5. Density: 1.36g/cm3
    6. Vapor Pressure: 3.89E-09mmHg at 25°C
    7. Refractive Index: 1.642
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile(71083-78-8)
    12. EPA Substance Registry System: 4-hydroxy-5,8-dimethoxyquinoline-3-carbonitrile(71083-78-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 71083-78-8(Hazardous Substances Data)

71083-78-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 71083-78-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,0,8 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 71083-78:
(7*7)+(6*1)+(5*0)+(4*8)+(3*3)+(2*7)+(1*8)=118
118 % 10 = 8
So 71083-78-8 is a valid CAS Registry Number.

71083-78-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Hydroxy-5,8-dimethoxy-3-quinolinecarbonitrile

1.2 Other means of identification

Product number -
Other names 5,8-dimethoxy-3-cyano-4-quinolone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71083-78-8 SDS

71083-78-8Relevant articles and documents

Synthesis of 5,8-dimethoxy-3-hydroxy-4-quinolone, a reported inhibitor of HIV RT, and evidence the original proposed structure was incorrect

Zembower, David E.,Aytes, Shelley A.

, p. 543 - 546 (1999)

An unambiguous total synthesis of the title compound, a semi-synthetic derivative reported to be a non-nucleoside reverse transcriptase inhibitor, was conducted in four steps from 2,5-dimethoxyaniline. The synthetic material differed from that reported in the literature, both in its physical properties and 1H NMR spectrum. Biological evaluation indicated that synthetic 2 was inactive against HIV-1 RT, suggesting that the previous structural assignment of the semi-synthetic derivative was incorrect.

Synthesis and structure-activity relationships of 3-cyano-4(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors

Zhang, Nan,Wu, Biqi,Powell, Dennis,Wissner, Allan,B. Floyd, Middleton,D. Kovacs, Eleonora,Toral-Barza, Lourdes,Kohler, Constance

, p. 2825 - 2828 (2007/10/03)

A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. (C) 2000 Elsevier Science Ltd.

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