71093-81-7Relevant academic research and scientific papers
PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
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Page/Page column 86; 87, (2016/05/02)
Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).
Palladium-containing ionic liquid-based ordered mesoporous organosilica: An efficient and reusable catalyst for the heck reaction
Elhamifar, Dawood,Karimi, Babak,Rastegar, Javad,Banakar, Mohammad Hossain
, p. 2418 - 2424 (2013/08/23)
The catalytic application of a novel palladium-containing periodic mesoporous organosilica with ionic liquid framework (Pd@PMO-IL-I) in the Heck cross-coupling reaction was described. This nanocatalyst was first synthesised and characterised by using diffuse reflectance infrared Fourier transform spectroscopy, thermogravimetric analysis, transmission electron microscopy and nitrogen sorption analysis. The efficiency of the Pd@PMO-IL-I catalyst was investigated in the Heck cross-coupling of various aryl halides with alkyl acrylates in the presence of N-methylpyrolidone at 140°C. The catalyst demonstrated excellent catalytic activity with various aryl iodides, aryl bromides, and activated aryl chlorides, which gave the corresponding coupling products in good to excellent yields and with excellent E-selectivities. Moreover, the recoverability, reusability and the actual nature of the Pd@PMO-IL-I catalyst were investigated to show the effect of ionic liquid moieties on the stabilisation of palladium species during the reaction. Our study showed that the catalyst could be recovered and reused at least nine times without any appreciable decrease in activity and selectivity, which confirmed its high efficiency and high stability under the reaction conditions and during recycling stages.
The ligand and base-free Pd-catalyzed oxidative Heck reaction of arylboronic acids and olefins
Sun, Peng,Zhu, Yan,Yang, Hailong,Yan, Hong,Lu, Linhua,Zhang, Xiang,Mao, Jincheng
supporting information; experimental part, p. 4512 - 4515 (2012/07/14)
Highly effective Pd-catalyzed Heck-type oxidative couplings between arylboronic acids and terminal olefins were reported. It is noteworthy that such reactions could be carried out in the absence of the base and the ligand.
Cinnamic, Phenylpropiolic and Phenylpropanoic Acid Derivatives Useful as Anti-Tumor Agents
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Page/Page column 10, (2008/12/07)
Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
CINNAMIC, PHENYLPROPIOLIC AND PHENYLPROPANOIC ACID DERIVATIVES USEFUL AS ANTI-TUMOUR AGENTS
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Page/Page column 34, (2008/06/13)
Cinnamic and phenylpropiolic acid derivatives of Formula (I) having antitumour and chemosensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
1-(2-Iodophenyl)-1H-tetrazole as a ligand for Pd(II) catalyzed Heck reaction
Gupta, Arun Kumar,Song, Chung Hyun,Oh, Chang Ho
, p. 4113 - 4116 (2007/10/03)
1-(2-Iodophenyl)-1H-tetrazole 2 was synthesized by the reaction of 2-iodoaniline, sodium azide and triethyl orthoformate in acetic acid. The newly synthesized ligand 2 was successfully used in Heck reaction to give the cross-coupled products in excellent yields.
