71094-17-2

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 532-27-4 1-chloroacetophenone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 

Downstream Products

• 159799-17-4 4,4a,5,6,7,7a-Hexahydro-3-phenyl-1-(4-methylbenzenesulfonyl)-1H-cyclopenta[c]pyridazine 

Relevant academic research and scientific papers

Oxidative Radical Addition-Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis

An unprecedented binary acid accelerated oxidative radical annulation of sulfonyl hydrazones with simple olefins is described. Notably, this method provides a novel oxidative radical cycloaddition for the construction of six-member heterocycles. It offers a rapid and efficient approach to tetrahydropyridazines which are key structural motifs in pharmaceutically active compounds.

1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines

Disclosed are progestin agonists having the following formula: STR1 W is absent or --CH=CH--; R1 are independently selected from the group consisting of halogen, --CF3, and NO2, or both R1 may be joined to form a bi-radical which is --CH=CHCH=CH--; R3 are independently selected from the group consisting of hydrogen, C1-6 branched or linear alkyl, halogen and --CF3, with the proviso that R3 at the 3-position must be H where R3 at the 4-position is H, or both R3 may be joined to form a bi-radical selected from the group consisting of --CH=CHCH=CH--, --C(NC1-4 alkyl2)=CHCH=CH-- and --(CH2)4 --; R5 is selected from the group consisting of H and Me; with the proviso that only one of R1 and R3 forms the fused bi-radical; and the stereoisomers.