71096-62-3Relevant academic research and scientific papers
Biomimetic Synyhesis of Heterocyclic β-Substituted Alanines by Pyridoxal 5'-Phosphate-Catalyzed Chemical Reactions
Murakoshi, Isamu,Ikegami, Fumio,Yoneda, Yoshihiro,Ihara, Harumi,Sakata, Kumiko,Koide, Chiharu
, p. 1473 - 1478 (2007/10/02)
Several heterocyclic β-substituted alanines were biomimetically synthesized by incubating 0.1M acetate buffer solution containing the appropriate heterocyclic compound and O-acetylserine or serine in the presence of pyridoxal 5'-phosphate (PLP) and metal ions.This PLP-catalyzed chemical reaction depends upon pH, metal ions and temperature.The addition of Ga3+, Fe3+ or Al3+ enhanced the rate of synthesis.The optimum of the various reaction conditions of this biomimetic method is described.Keywords - biomymetic synthesis; amino acid synthesis; heterocyclic β-substituted alanine; non-protein amino acid; O-acetylserine; N-heterocyclic compound; pyridoxal 5'-phosphate; metal ion
BIOSYNTHESIS OF β-(6-BENZYLAMINOPUTIN-9-YL)ALANINE, A METABOLITE OF VYTOKININ 6-BENZYLAMINOPURINE IN HIGHER PLANTS
Murakoshi, Isamu,Koide, Chiharu,Ikegami, Fumio,Nasu, Kikuko
, p. 1777 - 1779 (2007/10/02)
β-(6-benzylaminopurin-9-yl)alanine (3), a metabolite of the cytokinin 6-benzylaminopurine (2), was confirmed to be derived from O-acetyl-L-serine (1) and (2) by an enzyme in higher plants.Some properties of the enzyme are described.
SYNTHESIS OF OPTICALLY ACTIVE 9-PURINYL-α-AMINO ACIDS
Poritere, S.E.,Shluke, Ya.Ya.,Lidak, M.Yu.,Kilevitsa, M.K.
, p. 1308 - 1313 (2007/10/02)
A general method for the synthesis of optically active 9-purinyl-α-amino acids by condensation of 5-amino-4,6-dichloropyrimidine with α,ω-diamino carboxylic acids and subsequent cyclization of the Nω-(5-amino-4-chloro-6-pyrimidinyl)-amino acids with triethyl orthoformate was developed.A number of 6-substituted α-amino-ω-(9-purinyl)carboxylic acids were obtained by nucleophilic substitution of the chlorine atom in the α-amino-ω-(6-chloro-9-purinyl)carboxylic acids.
