711007-07-7Relevant academic research and scientific papers
Synthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor
Yoo, Ho,Lee, Jae Yeol,Park, Jang Hyun,Chung, Bong Young,Lee, Yong Sup
, p. 1243 - 1250 (2007/10/03)
A series of styrylbenzofuran derivatives (8a-i) as styrylquinoline isosters were efficiently prepared by Wittig reaction and evaluated for inhibitory activity against HIV-1 integrase. In this series, compounds 8g, 8h and 8i containing a free catechol ring showed moderate inhibitory activities (IC50=～40 μM) against HIV-1 integrase, while less than the corresponding styrylquinoline compound (I).
