711017-84-4Relevant academic research and scientific papers
Design and synthesis of potential dual NK1/NK3 receptor antagonists
Hanessian, Stephen,Babonneau, Vincent,Boyer, Nicolas,Mannoury La Cour, Clotilde,Millan, Mark J.,De Nanteuil, Guillaume
, p. 510 - 514 (2014)
The tachykinin NK1 and NK3 receptors are a novel drug target for schizophrenia in order to treat not only the positive and cognitive symptoms, but also the associated co-morbid depression and sleep disturbances associated with the di
Asymmetric carbamoyl anion additions to chiral N-phosphonyl imines via the GAP chemistry process and stereoselectivity enrichments
Seifert, Cole W.,Pindi, Suresh,Li, Guigen
, p. 447 - 452 (2016/09/12)
Carbamoyl anions were found to smoothly react with chiral N-phosphonyl imines in toluene at -78 °C to r.t. using LiHMDS as the base. Group-assisted purification (GAP) has been utilized to give the pure amides without using column chromatography or recryst
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
Li, Jin,Bertinato, Peter,Cheng, Hengmiao,Cole, Bridget M.,Bronk, Brian S.,Jaynes, Burton H.,Hickman, Anne,Haven, Michelle L.,Kolosko, Nicole L.,Barry, Chris J.,Manion, Tara B.
, p. 3039 - 3042 (2008/09/20)
We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.
PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA
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Page 64-65, (2010/02/07)
The invention relates to compounds of formula (I), wherein : R1 represents hydrogen, C1-4 alkyl, -CH2CO2H, -CH2CO2C1-2alkyl, or -CH2CONR7R8; Rsu
