71107-19-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Oxo-5-vinylpyrrolidine-3-carboxamide is used as an intermediate compound for the synthesis of various pharmaceutical products. Its role in the preparation of diaminoalkenes makes it a valuable component in the development of new drugs and therapeutic agents.
Used in Analytical Chemistry:
In the field of analytical chemistry, 2-Oxo-5-vinylpyrrolidine-3-carboxamide is employed for the separation of vigabatrin from other compounds using high-performance liquid chromatography (HPLC) and macroporous polymeric columns. This application aids in the accurate analysis and identification of vigabatrin, which is crucial for quality control and research purposes.
Used in Chemical Research:
2-Oxo-5-vinylpyrrolidine-3-carboxamide serves as a key compound in chemical research, particularly in the study of copper-mediated diamination reactions. Its involvement in the synthesis of diaminoalkenes contributes to the advancement of chemical knowledge and the development of novel chemical processes and applications.

InChI:InChI=1/C7H10N2O2/c1-2-4-3-5(6(8)10)7(11)9-4/h2,4-5H,1,3H2,(H2,8,10)(H,9,11)

Upstream product

• 7686-78-4 diethyl 2-vinylcyclopropane-1,1-dicarboxylate 
• 77287-34-4 formamide 

Relevant academic research and scientific papers

A convenient approach for vinylation reaction in the synthesis of 5-vinyl-2-pyrrolidinone, a key intermediate of vigabatrin

A convenient, safe and cost-effective method for carrying out the key vinylation of 5-ethoxy-2-pyrrolidinone (8) in the preparation of 5-vinyl-2-pyrrolidinone (2) in the presence of potassium carbonate is described. This present procedure is developed by replacing inherently hazardous ethyl magnesium bromide with inexpensive and eco-friendly potassium carbonate. The reaction was performed on a multi-gram scale, with vinyl magnesium bromide as the vinylation reagent, in an 81% yield to give the 5-vinyl-2-pyrrolidinone with excellent purity and without the need for chromatography.

Preparation method of aminohexenoic acid

The invention discloses a preparation method of aminohexenoic acid, which is characterized by comprising the following steps: with diethyl malonate and 1,4-dichloro-2-butene as raw materials, preparing 2-vinylcyclopropane-1,1-dicarboxylic acid diethyl ester; then carrying out a reaction on 2-vinylcyclopropane-1,1-dicarboxylic acid diethyl ester in the presence of ammonia and formamide to prepare 2-carbonyl-5-vinyl-pyrrolidine-3-amide; preparing a 4-amino-5-hexenoic acid crude product from the 2-carbonyl-5-vinyl-pyrrolidine-3-amide under an acidic condition; then preparing triisopropylsilyl-4-aminohexyl-5-alkenyl ester from 4-amino-5-hexenoic acid and triisopropylchlorosilane in the presence of triethylamine and ammonia; recrystallizing the triisopropylsilyl-4-aminohexyl-5-alkenyl ester inchloroform/methanol to obtain a purified product of the triisopropylsilyl-4-aminohexyl-5-alkenyl ester; wherein the volume ratio of chloroform to methanol is 1:7; and hydrolyzing the purified productof the triisopropylsilyl-4-aminohexyl-5-alkenyl ester under an alkaline condition to obtain the aminohexylenic acid.

Process for making 4-aminohex-5-enoic acid

Novel compounds of the following general formula are useful in the preparation of 4-aminohex-5-enoic acid and 4-aminohex-5-ynoic acid which are useful pharmacological agents: STR1 wherein R1 is hydroxy, amino, or tert-butoxy.