711237-63-7Relevant academic research and scientific papers
Novel cyclic 1,2-diacetals derived from (2R,3R)-(+)-tartaric acid: Synthesis and application as N,O ligands for the enantioselective alkylation of benzaldehyde by diethylzinc
Barros, M. Teresa,Maycock, Christopher D.,Phillips, Ana Maria Faisca
, p. 1820 - 1829 (2004)
A chiral cyclic 1,2-diacetal derived from tartaric acid was used as the basic structural unit for novel ligands. Monooxazoline carbinols in which the degree of substitution of the alcohol and the nature of the stereocentre in the oxazoline ring were varied were synthesized in moderate to good yields. The influence of these structural factors on asymmetric induction was examined in the enantioselective addition of diethylzinc to benzaldehyde. Up to 60% ee was observed with a secondary or a tertiary alcohol as the metal-chelating group. Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2004.
