7118-95-8

Basic information

• Product Name: N-(5-methyl-[1,3,4]thiadiazol-2-yl)-N-phenyl-acetamide
• Synonyms: N-(5-methyl-[1,3,4]thiadiazol-2-yl)-N-phenyl-acetamide
• CAS NO: 7118-95-8
• Molecular Weight: 233.294
• Mol File: 7118-95-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(5-methyl-[1,3,4]thiadiazol-2-yl)-N-phenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-methyl-[1,3,4]thiadiazol-2-yl)-N-phenyl-acetamide(7118-95-8)
• EPA Substance Registry System: N-(5-methyl-[1,3,4]thiadiazol-2-yl)-N-phenyl-acetamide(7118-95-8)

Safety Data

• Hazardous Substances Data: 7118-95-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 

Relevant articles and documents

Cyclization Reactions of Tricarbonylmethane Thiosemicarbazones: Formation of 1,3,4-Thiadiazole Derivatives with Concomitant C-C Bond Cleavage

Under acylating conditions 3-acetyl-4-hydroxy-2H-pyran-2-one thiosemicarbazones (1a, b and 2a, b) are transformed into 2-(acylamino)-5-methyl-1,3,4-thiadiazoles 3b, c, e, f and 2H-pyran-2-ones 1c and 2c via C-C bond cleavage.Similarly, the reaction of 1b with RCO2H/EtOH (R = Me, Et) affords 2-anilino-5-methyl-1,3,4-thiadiazole (3d) and triacetic acid lactone 1c.Upon treatment with Ac2O/Et3N the dehydroacetic acid derivative 1b is transformed into the thiadiazoline 4, while the benzo derivative 2b is converted into thiadiazole 3e and 4-acetoxycoumarin (2c). - Key Words: 2H-Pyran-2-ones / Coumarins / 1,3,4-Thiadiazoles / Thiosemicarbazones