71184-91-3

Upstream product

• 93-97-0 benzoic acid anhydride 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 131615-74-2 methyl 2-N-benzoylamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside 

Downstream Products

• 736993-85-4 2-oxo-4-[(2-trimethylsilanyl-ethanesulfonyl)-(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide 
• 736993-87-6 2-oxo-4-[(5-trimethylsilanyl-1H-pyrrole-2-carbonyl)-amino]-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide 
• 736993-91-2 5-Trimethylsilanyl-1H-pyrrole-2-carboxylic acid [(1R,4R,5S)-5-(3-benzyl-3-methyl-ureido)-4-hydroxy-cyclopent-2-enyl]-amide 
• 736993-75-2 5-Trimethylsilanyl-1H-pyrrole-2-carboxylic acid [(1R,5S)-5-(3-benzyl-3-methyl-ureido)-4-oxo-cyclopent-2-enyl]-amide 
• 736993-83-2 (3aS,4R,6aR)-2-Oxo-4-(2-trimethylsilanyl-ethanesulfonylamino)-4,6a-dihydro-3aH-cyclopentaoxazole-3-carboxylic acid benzyl-methyl-amide 
• 736993-78-5 1-benzyl-3-(2,5-dioxo-2,3,3a,4,5,8b-hexahydro-1H-4,8a-diaza-as-indacen-3-yl)-1-methyl-urea 
• 800393-36-6 C₁₉H₁₉BrN₄O₃ 
• 800393-37-7 C₁₉H₁₇Br₃N₄O₃ 
• 213123-40-1 N-((2R,4aR,6S,7R,8R,8aS)-8-Azido-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-benzamide 
• 213123-42-3 N-((2R,4aR,6S,7S,8S,8aS)-7-Azido-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-benzamide 
• 213123-43-4 N-((2R,4aR,6S,7S,8S,8aS)-7-Amino-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl)-benzamide 
• 592527-26-9 methyl 2,3-dideoxy-3-methoxycarbonylamino-6-O-toluenesulphonyl-4-O-triethylsilyl-2-trimethylsilylethylsulfonamido-α-D-altropyranoside 
• 592527-22-5 methyl 2,3-dideoxy-3-methoxycarbonylamino-6-O-toluenesulphonyl-2-trimethylsilylethylsulfonamido-α-D-altropyranoside 
• 592527-04-3 methyl 4,6-O-benzylidene-2,3-dideoxy-3-methoxycarbonylamino-2-trimethylsilylethylsulfonamido-α-D-altropyranoside 

Relevant academic research and scientific papers

Synthesis and in vitro activities of a spacer-containing glycophospholipid ligand of a lipopolysaccharide receptor involved in endotoxin tolerance

A glycophospholipid consisting in a derivative of N,N'-acylated and bisphosphorylated 2,3-dideoxy-2,3-diamino-d-glucose, bearing a 6-aminocaproyl side chain as spacer arm at carbon 6 (PPDm2-B), has been synthesized and its effect on murine macrophages evaluated. The synthesis started from 2,3-diamino-d-glucose, which was best obtained from glucosamine essentially by known procedures, since attempts to use another known precursor (3-nitro-glycoside) led to unexpected results. Selective N-acylation was performed with the hydroxysuccinimide ester of (d)-3-benzyloxymyritic acid followed by esterification of the sole primary hydroxyl function by 6-azidocaproylchloride and phosphorylation of the resulting 1,4-diol by treatment with tetrabenzyl pyrophosphate. Hydrogenation on a Pd on carbon catalyst permitted the isolation of 6-(6-aminohexanoyl)-2,3-dideoxy-2,3-di-[(R)-3-hydroxy-tetradecanamido]-α-d-glucopyranose 1,4-diphosphate (PPDm2-B). In mouse macrophages, PPDm2-B enhanced the lipopolysaccharide (LPS)-dependent secretion of tumor necrosis factor alpha (TNF-α), and inhibited the LPS-induced desensitization of these cells. The data suggest that PPDm2-B interacts in a serum-independent way with an LPS receptor different from CD14, and involved in endotoxin tolerance. Binding studies of a fluorescent derivative of PPDm2-B indicated that the expression of this unknown receptor is down-regulated during in vitro culture of the cells. Owing to its spacer arm, PPDm2-B could thus be a promising tool for future studies of this receptor. Copyright (C) 1998 Elsevier Science Ltd.

MOLECULES AND ANALOGUES OF THE AGELASTATIN FAMILY OF ANTITUMOUR AND GSK-3β-INHIBITING ALKALOIDS

A compound of general structure (I); or, a pharmaceutically acceptable salt thereof, wherein, C---A and Z---C = independently a single or a double bond; A = C, N, O, S, or Se; Z = C, N, 0, S, or Se; R1, R2, R3, R7/su