71186-11-3

Upstream product

• 623-43-8 methyl crotonate 
• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 74346-08-0 (2E,4E)-methyl 2-carboxy-5-(3,5-dibenzyloxyphenyl)penta-2,4-dienoate 
• 13395-34-1 (3-(methoxycarbonyl)propyl)triphenylphosphonium bromide 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 4897-84-1 Methyl 4-bromobutyrate 
• 74333-66-7 methyl 2-carboxy-5-(3,5-dihydroxyphenyl)pentanoate 
• 24131-31-5 3,5-dibenzyloxybenzyl alcohol 
• 58605-10-0 methyl 3,5-bis(benzyloxy)benzoate 

Downstream Products

• 74333-70-3 (3R,4R)-ω-carboxy-Δ¹-tetrahydrocannabinol 
• 63998-82-3 (3R,4R)-ω-carboxy-p-cannabidiol 
• 74333-68-9 (3R,4R)-ω-methoxycarbonyl-p-cannabidiol 
• 74333-67-8 (3R,4R)-ω-methoxycarbonyl-o-cannabidiol 
• 120467-27-8 5-[3,5-Dihydroxy-2,4-bis-((1R,6R)-6-isopropenyl-3-methyl-cyclohex-2-enyl)-phenyl]-pentanoic acid methyl ester 

Relevant academic research and scientific papers

CANNABIDIOL-CONTAINING COMPOSITIONS AND USES THEREOF

Compositions comprising a cell-derived particle associated with Cannabidiol (CBD), and uses thereof in treating medical conditions that can benefit from Cannabidiol (CBD) are provided.

Synthesis of Cannabinoids Carrying ω-Carboxy Substituents: The Cannabidiols, Cannabinol and Δ1- and Δ6-Tetrahydrocannabinols of this Series

A convenient synthesis of methyl 5-(3,5-dihydroxyphenyl)pentanoate adaptable for isotopic side-chain labelling is reported.Using acid-catalysed terpenylations involving (1S,4R)-(+)-trans-p-menthadienol, conditions for making (3R,4R)-o- and p-cannabidiols,

Synthesis of Cannabinoid Model Compounds. Part 2): (3R,4R)-δ1(6)-Tetrahydrocannabinol-5"-oic Acid and 4"(R,S)-Methyl-(3R,4R)-δ1(6)-Tetrahydrocannabinol-5"-oic Acid

Two novel cannabinoid model compounds, (3R,4R)-Δ1(6)-tetrahydrocannabinol-5"-oic acid (22) and 4"(R,S)-methyl-(3R,4R)-Δ1(6)-tetrahydrocannabinol-5"-oic acid (23) were synthesized by acid-catalyzed condensation of (+)-trans-p-mentha-2,8-dien-1-ol (1) with the substituted resorcinols 18 and 19 obtained by a Wittig reaction between 3,5-bis(benzyloxy)benzaldehyde (7) and methyl 4-bromobutanoate (10) or methyl 4-bromo-2(R,S)-methylbutanoate (11) resp. with subsequent hydrogenation.The resulting methyl esters 20 and 21 were hydrolyzed to give acids 22 and 23.

Synthesis and psychotropic activity of side-chain hydroxylated Δ6-tetrahydrocannabinol metabolites

Syntheses of the five side chain mono-hydroxylated Δ6-tetrahydrocannabinol derivatives are described. On the basis of behavioural tests with these compounds in rhesus monkeys, it was concluded that hydroxylation at the benzylic C-1' position sharply reduces 'Cannabis tup' activity annabis ttypactivity as compared to Δ6-THC; that on C-2' causes some reduction in activity, whereas hydroxylations at the other positions cause no changes.