71186-69-1Relevant academic research and scientific papers
Fused tetracyclic compounds and application thereof in medicines
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Paragraph 0218; 0220-0222, (2020/05/30)
The invention relates to fused tetracyclic compounds and application thereof in medicines, in particular to application of the fused tetracyclic compounds as medicines for treating and/or preventing hepatitis B. Specifically, the present invention relates to compounds represented by a general formula (I) which is described in the specification or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, wherein all the variables are as defined in the specification. The invention further relates to application of the compounds as shown in the general formula (I) or the stereoisomers, the tautomers, the nitric oxides, the solvates, the metabolites, the pharmaceutically acceptable salts or the prodrugs of the compounds as medicines, particularly as medicines for treating and/or preventing hepatitis B.
Visible-Light-Induced External Radical-Triggered Annulation to Access CF2-Containing Benzoxepine Derivatives
Xiang, Haoyue,Zhao, Qing-Lan,Xia, Peng-Ju,Xiao, Jun-An,Ye, Zhi-Peng,Xie, Xiong,Sheng, Huan,Chen, Xiao-Qing,Yang, Hua
supporting information, p. 1363 - 1366 (2018/03/09)
A facile and diversified synthesis of functionalized CF2-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which would facilitate its practical and broad applications in the construction of valuable and synthetically challenging heterocycles.
Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives
Juhasz, Laszlo,Docsa, Tibor,Brunyaszki, Attila,Gergely, Pal,Antus, Sandor
, p. 4048 - 4056 (2008/03/12)
Novel 5-benzyl and 5-benzylidene-thiazolidine-2,4-diones carrying 2,3-dihydrobenzo[1,4]dioxin pharmacophore were synthesized and their glycogen phosphorylase inhibitor activity was also studied.
