7119-12-2

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 402757-06-6 1-(4-Fluoro-phenyl)-1-methyl-propylamine 
• 97872-16-7 2-Benzo[d]isoxazol-3-yl-N-[1-(4-fluoro-phenyl)-1-methyl-propyl]-acetamide 
• 97872-25-8 2-Benzo[d]isoxazol-3-yl-N-[1-(4-fluoro-phenyl)-1-methyl-propyl]-butyramide 

Relevant academic research and scientific papers

Reactions of Et3ZnLi with ketones: Electronic and steric effects

Toluene solutions of composition Et3ZnLi react rapidly with aldehydes and ketones to form addition products. Et3ZnNa and Et3ZnK solutions react readily with the same substrates although metalation, as well as addition, is significant with substrates having α-hydrogens. The Et3ZnM solutions react with 2-cyclohexenone to give mainly the 1,4-addition product. Relative rates of addition of Et3ZnLi to substituted acetophenones give a Hammett ρ of 2.78. Addition of Et3ZnLi to acetophenone is slowed significantly by α and ortho methyl substituents; relative rates of addition to acetophenone, o-methylacetophenone, and tert-butyl phenyl ketone are 1.00, 0.012, and 0.003.

Synthesis and Herbicidal Activities of 1,2-Benzisoxazole-3-acetamide Derivatives

Many 1,2-benzisoxazole-3-acetamides were synthesized and their herbicidal activities in the paddy field were studied.Of the compounds tested, N-α,α-dimethylbenzyl-2-bromo-(1,2-benzisoxazol-3-yl)acetamide 10a was the most effective.Details of the synthesis and the results of herbicidal evaluations are given.