7119-40-6Relevant academic research and scientific papers
Three-component one-pot process to propargylic amines and related amide and sulfonamide compounds: application to the construction of 2-(aminomethyl)benzofurans and indoles
Russo, Olivier,Messaoudi, Samir,Hamze, Abdallah,Olivi, Nathan?el,Peyrat, Jean-Fran?ois,Brion, Jean-Daniel,Sicsic, Sames,Berque-Bestel, Isabelle,Alami, Mouad
, p. 10671 - 10683 (2008/02/12)
An efficient palladium-copper-catalyzed three-component assembling of propargyl halides, aryl or heteroaryl halides, and secondary amines is described. A wide variety of tertiary propargylic amines were synthesized in good to excellent yields from easily accessible starting materials. This three-component assembling was also effective when using potassium phthalimide or di-tert-butyliminodicarbonate instead of secondary amines. Consequently, it provides a quick entry to N-protected propargylic amines suitable intermediates for the synthesis of primary and secondary propargylic amines. In a similar way, related compounds including propargylic amide, carbamate and sulfonamide derivatives were efficiently obtained. This catalytic domino three-component process has been applied successfully to the construction of functionalized 2-(aminomethyl)benzo[b]furan or indole derivatives of biological interest.
Tandem amine propargylation-Sonogashira reactions: New three-component coupling leading to functionalized substituted propargylic amines
Olivi, Nathana?l,Spruyt, Philippe,Peyrat, Jean-Fran?ois,Alami, Mouad,Brion, Jean-Daniel
, p. 2607 - 2610 (2007/10/03)
Three-component coupling reactions of propargyl halides, amines, and organic halides in the presence of palladium-copper catalysis produced efficiently highly functionalized propargylic amines in good to excellent yields at room temperature. Extension to
