71200-91-4

Upstream product

• 87769-44-6 6-(4-methoxyphenyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 95-54-5 1,2-diamino-benzene 
• 31709-47-4 3-(4-methoxyphenyl)isoxazol-5(4H)-one 
• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 55991-69-0 5-(4-methoxyphenyl)-2,3-dihydro-2,3-furandione 

Downstream Products

• 1337994-35-0 1-benzyl-4-(4-methoxyphenyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one 
• 1189734-22-2 1-benzyl-4-(4-methoxyphenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one 

Relevant academic research and scientific papers

Asymmetric Ir-catalyzed hydrogenation of 1,3-dihydro-2H-1,5-benzodiazepin-2-ones using phosphoramidites

A series of phosphoramidite ligands was tested in the asymmetric hydrogenation of 4-arylsubstituted 1,3-dihydro-2H-benzodiazepine-2-ones and up to 52% ee was achieved. The effects of various factors (solvents, hydrogen pressure, and addition of phosphine

Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon

Unsubstituted and 7- or 8-substituted 4-aryl-1H-1,5-benzodiazepin-2(3H)-ones 3a-t have been synthesized by the condensation of 3-aryl-5(4H)-isoxazolones 1a-e and parent 4-substituted 1,2-benzenediamines 2a-d under acidic conditions.

REACTION OF 2,2-DIMETHYL-6-ARYL-1,3-DIOXIN-4-ONES WITH AROMATIC AMINES AND o-PHENYLENEDIAMINE

N-Arylaroylacetamides and 4-aryl-1,5-benzodiazepin-4-ones were obtained by the thermolysis of 2,2-dimethyl-6-aryl-1,3-dioxin-4-ones in the presence of aromatic amines and o-phenylenediamine respectively.Investigetion of the reaction kinetics showed that the controlling stage is the generation of the aroylketenes, which takes place by a concerted -retrocycloaddition mechanism.