71206-74-1Relevant academic research and scientific papers
Green synthesis and antiviral activity of novel triarylmethane derivatives via Friedel-Crafts alkylation by polyethylene glycol (PEG-400)
Revaprasadu,Sampath,Harika
, p. 473 - 478 (2016)
A series of novel triarylmethane derivatives (3a-j) were synthesized by a one-pot, two-component method via Friedel-Crafts alkylation of various electron-rich arenes (1a-j) with a wide variety of aldehydes (2a-j) in presence of the polyethylene glycol (PEG-400) as a green solvent at 50-60 °C in good to excellent yields (76-96 %). Their structures were confirmed by FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. All the triarylmethanes were tested and evaluated for their antiviral and antifungal activities. Compounds 3b, 3f, 3g and 3i exhibited highest antiviral activities against tobacco mosaic virus (TMV).
A rapid, highly efficient, and general protocol for the synthesis of functionalized triarylmethanes: A straightforward access for the synthesis of (-)-tatarinoid C
Babu, B. Madhu,Thakur, Pramod B.,Nageswara Rao,Santosh Kumar,Meshram
, p. 1868 - 1872 (2014/03/21)
A rapid, efficient, and convenient synthesis of functionalized triarylmethane is described by the Friedel-Crafts alkylation of methoxybenzenes with a variety of aldehydes in the presence of BF3·OEt 2. The generality of the method is demonstrated by screening a variety of di- or tri-substituted arenes as well as substituted aromatic, heteroaromatic, and aliphatic aldehydes. (-)-Tatarinoid C is synthesized in a single step following the same protocol.
