712281-38-4

Upstream product

• 108-40-7 toluene-3-thiol 
• 607389-13-9 N-tert-butoxycarbonyl-3,6-imino-4,5-O-isopropylidene-7-O-methanesulfonyl-2,3,6-trideoxy-D-allo-heptononitrile 
• 222631-50-7 N-tert-butoxycarbonyl-3,6-imino-4,5-O-isopropylidene-2,3,6-trideoxy-D-allo-heptononitrile 
• 222631-09-6 (3aR,4R,6S,6aS)-tert-butyl 4-(((tert-butyldimethylsilyl)oxy)methyl)-6-(cyanomethyl)-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate 

Relevant academic research and scientific papers

Targeting the polyamine pathway with transition-state analogue inhibitors of 5′-methylthioadenosine phosphorylase

The polyamine biosynthetic pathway is a therapeutic target for proliferative diseases because cellular proliferation requires elevated levels of polyamines. A byproduct of the latter stages of polyamine biosynthesis (the synthesis of spermidine and spermi