7123-77-5 Usage
Uses
Used in Pharmaceutical Synthesis:
4-(1-ADAMANTYL)ANILINE HYDROCHLORIDE is used as a building block for the synthesis of various pharmaceuticals, leveraging its stable and soluble characteristics to contribute to the development of new medications.
Used in Organic Compounds Synthesis:
In the realm of organic chemistry, 4-(1-ADAMANTYL)ANILINE HYDROCHLORIDE serves as a key component in the creation of diverse organic compounds, thanks to its reactive functional groups and structural attributes.
Used in Dye and Pigment Production:
4-(1-ADAMANTYL)ANILINE HYDROCHLORIDE is utilized in the production of dyes and pigments, capitalizing on its chemical properties to enhance colorfastness and stability in various applications.
Used in Medicinal Chemistry and Drug Development:
Due to its unique structure, 4-(1-ADAMANTYL)ANILINE HYDROCHLORIDE is applied in medicinal chemistry and drug development, potentially leading to the discovery of novel therapeutic agents.
Used in Industrial Applications:
Beyond the laboratory, 4-(1-ADAMANTYL)ANILINE HYDROCHLORIDE finds use in various industrial applications, where its chemical properties are harnessed for specific technical needs.
Check Digit Verification of cas no
The CAS Registry Mumber 7123-77-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,2 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7123-77:
(6*7)+(5*1)+(4*2)+(3*3)+(2*7)+(1*7)=85
85 % 10 = 5
So 7123-77-5 is a valid CAS Registry Number.
InChI:InChI=1S/C16H21N.ClH/c17-15-3-1-14(2-4-15)16-8-11-5-12(9-16)7-13(6-11)10-16;/h1-4,11-13H,5-10,17H2;1H
7123-77-5Relevant academic research and scientific papers
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid
Mélin, Léa,Abdullayev, Shuay,Fnaiche, Ahmed,Vu, Victoria,González Suárez, Narjara,Zeng, Hong,Szewczyk, Magdalena M.,Li, Fengling,Senisterra, Guillermo,Allali-Hassani, Abdellah,Chau, Irene,Dong, Aiping,Woo, Simon,Annabi, Borhane,Halabelian, Levon,LaPlante, Steven R.,Vedadi, Masoud,Barsyte-Lovejoy, Dalia,Santhakumar, Vijayaratnam,Gagnon, Alexandre
, p. 2982 - 3002 (2021/08/03)
The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibition of TEAD represses the expression of associated genes, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies. We report herein the design, synthesis and biological evaluation of LM98, a flufenamic acid analogue. LM98 shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. Binding of LM98 to TEAD was supported by 19F-NMR studies while co-crystallization experiments confirmed that LM98 is anchored within the palmitic acid pocket of TEAD. LM98 reduces the expression of CTGF and Cyr61, inhibits MDA-MB-231 breast cancer cell migration and arrests cell cycling in the S phase during cell division.
