71240-74-9

Upstream product

• 71240-70-5 2,5-di-O-acetyl-3,4-di-O-methyl-1,6-di-O-methylsulfonyl-D-mannitol 
• 71240-64-7 O¹,O²;O⁵,O⁶-diisopropylidene-O³,O⁴-dimethyl-D-mannitol 
• 17288-98-1 O³,O⁴-dimethyl-D-mannitol 

Relevant academic research and scientific papers

SYNTHESIS OF "DOUBLE-HEADED" BIS-HOMONUCLEOSIDE ANALOGS

The synthesis of "double-headed" bis-homonucleoside analogs, containing an oxolane ring with D-arabo and L-lyxo configuration is described.As starting material differently substituted 1,6-diazido-1,6-dideoxy-2,5-anhydro-D-glucitol and L-iditol derivatives

1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the preparation thereof

The invention relates to 1,6-dimesyl-3,4-dimethyl-D-mannitol of the formula (I), STR1 wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases. 1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D-mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), STR2 wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.