71254-91-6

Basic information

• Product Name: 1-(P-TOSYL)-3,4,4-TRIMETHYL-2-IMIDAZOLINIUM IODIDE
• Synonyms: 1-(P-TOSYL)-3,4,4-TRIMETHYL-2-IMIDAZOLINIUM IODIDE;1-(P-tosyl)-3,4,4-trimethyl-2-imidazolinium iodid;1-(P-TOSYL)-3 4 4-TRIMETHYL-2-
• CAS NO: 71254-91-6
• Molecular Formula: C₁₃H₁₉N₂O₂S*I
• Molecular Weight: 394.27
• Product Categories: Heterocyclic Compounds
• Mol File: 71254-91-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 178-181 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 1-(P-TOSYL)-3,4,4-TRIMETHYL-2-IMIDAZOLINIUM IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(P-TOSYL)-3,4,4-TRIMETHYL-2-IMIDAZOLINIUM IODIDE(71254-91-6)
• EPA Substance Registry System: 1-(P-TOSYL)-3,4,4-TRIMETHYL-2-IMIDAZOLINIUM IODIDE(71254-91-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 71254-91-6(Hazardous Substances Data)

Usage

General Description

1-(P-Tosyl)-3,4,4-trimethyl-2-imidazolinium iodide is a chemical compound with the molecular formula C15H24IN2O2S. It is a quaternary salt that is commonly used in organic synthesis as a highly selective and efficient catalyst in a variety of reactions. 1-(P-TOSYL)-3,4,4-TRIMETHYL-2-IMIDAZOLINIUM IODIDE is known for its ability to facilitate the formation of carbon-heteroatom bonds, particularly in the synthesis of biologically active molecules and pharmaceuticals. Additionally, it has been found to be a valuable reagent in the formation of carbon-carbon bonds through cross-coupling reactions. The presence of the tosyl group ensures stability and compatibility with a variety of reaction conditions, making this compound a versatile and valuable tool in the field of organic chemistry.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 2305-59-1 4,4-dimethyl-2-imidazoline 
• 71254-89-2 1-p-toluenesulfonyl-4,4-dimethyl-Δ²-imidazoline 
• 74-88-4 methyl iodide 

Downstream Products

• 1968-05-4 3,3'-diindolylmethane 
• 120-73-0 purine 
• 93630-96-7 2-methoxycarbonyl-α-(methoxycarbonyl)-β-tryptaminyl-styrene 
• 93630-97-8 2-methoxycarbonyl-α-(methoxycarbonyl)-β-tryptaminyl-styrene 
• 88939-57-5 2-<2-(1-tosyl-3,4,4-trimethylimidazolidinyl)>phenyl-1,3-dithiane 
• 88939-58-6 2<2-(1-tosyl-3,4,4-trimethylimidazolidinyl)>-3'-methoxyphenyl-1,3-dithiane 
• 100942-48-1 ethyl (E)-5-<2-(tosylamino-1,1-dimethyl)ethyl methyl>amino-2,2-dimethyl-3-oxo-4-pentenoate 
• 88839-24-1 ethyl-4-<2-(1-tosyl-3,4,4-trimethyl)imidazolidinyl>-2,2-dimethyl-3-oxo-butanoate 
• 93630-94-5 2-methoxycarbonyl-α-(methoxycarbonyl)-β-<2-(tosylamino-1,1-dimethyl)ethyl>methylaminostyrene 
• 93630-90-1 2-{Methoxycarbonyl-[3,4,4-trimethyl-1-(toluene-4-sulfonyl)-imidazolidin-2-yl]-methyl}-benzoic acid methyl ester 
• 93630-90-1 methyl 2(methoxycarbonyl)-α-<2-(1-tosyl-3,4,4-trimethyl)imidazolidinyl>-1-phenylacetate 
• 73955-63-2 2-benzyl-3,4,4-trimethyl-1-(toluene-4-sulfonyl)-imidazolidine 
• 83925-54-6 Ethyl 5<(1,1-dimethyl-2-tosylamino)ethylmethyl>amino-3-oxo-4-pentenoate 
• 127699-05-2 (E)-5-{[1,1-Dimethyl-2-(toluene-4-sulfonylamino)-ethyl]-methyl-amino}-3-oxo-pent-4-enoic acid methyl ester 

Relevant articles and documents

MODELS OF FOLATE COENZYMES-VII SYNTHESIS AND CARBON TRANSFER REACTIONS OF N5,N10-METHENYL AND N5,N10-METHYLENETETRAHYDROFOLATE MODELS

Carboxylate esters react with 1,2-diaminoethanes to yield imidazolines, which upon consecutive reaction with acetic anhydride or tosyl chloride and methyl iodide give imidazolinium salts that serve as models of N5,N10-(CH+)-tetrahydrofolate (THF) coenzymes (7a,b and 18a,b).Reduction of the latter salts with sodium borohydride or reaction with anions (R-) give the corresponding 5,10--THF models.Mono- and bifunctional nucleophiles react with 18a,b to yield carbon-transfer products. 6-Alkylamino-1,3-dimethyluracils react with 1-tosyl-3,4,4-trimethylimidazolidine (the reduction product of 18b), in the presence of acetic acid, to form carbon-transfer products via a mechanism which bears close analogy to the mechanism of action of thymidylate synthetase.