71257-58-4Relevant academic research and scientific papers
General Method for the Asymmetric Synthesis of N-H Sulfoximines via C-S Bond Formation
Argent, Stephen P.,Lewis, William,Mendon?a Matos, Priscilla,Moore, Jonathan c.,Stockman, Robert A.
, (2020)
A versatile method for the synthesis of enantioenriched N-H sulfoximines is reported. The approach stems from the organomagnesium-mediated ring opening of novel cyclic sulfonimidate templates. The reactions proceed in high yield and with excellent stereofidelity with alkyl, aryl, and heteroaryl Grignard reagents. The chiral auxiliary is readily removed from the resultant sulfoximines via an unusual oxidative debenzylation protocol that utilizes molecular oxygen as the terminal oxidant. This provides a general strategy for the synthesis of highly enantioenriched N-H sulfoximines.
Certain heterocyclic sulfoximide derivatives
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, (2008/06/13)
Sulphoximide derivatives of the general formula: STR1 wherein R1 is a phenyl, thienyl, furyl or pyridyl ring; R2 is a thienyl, furyl, or pyridyl ring; R3 and R4 are the same or are different and are alkyl groups
