71258-98-5Relevant academic research and scientific papers
First total synthesis of yanuthones: Novel farnesylated epoxycyclohexenoid marine natural products
Mehta, Goverdhan,Pan, Subhas Chandra
, p. 5219 - 5223 (2005)
The total synthesis of the recently isolated marine natural products of mixed biosynthetic origin, yanuthones A, B, C and 22-deacylyanuthone A, has been accomplished following a short regio- and stereocontrolled approach involving the key intermediacy of
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease
Tommonaro, Giuseppina,García-Font, Nuria,Vitale, Rosa Maria,Pejin, Boris,Iodice, Carmine,Ca?adas, Sixta,Marco-Contelles, José,Oset-Gasque, María Jesús
, p. 326 - 338 (2016/07/07)
Avarol is a marine sesquiterpenoid hydroquinone, previously isolated from the marine sponge Dysidea avara Schmidt (Dictyoceratida), with antiinflammatory, antitumor, antioxidant, antiplatelet, anti-HIV, and antipsoriatic effects. Recent findings indicate
Direct allylation of quinones with allylboronates
Deng, Hong-Ping,Wang, Dong,Szabó, Kálmán J.
, p. 3343 - 3348 (2015/03/30)
Allylboronates undergo C-H allylation of unsubstituted or monosubstituted benzoquinone and naphthoquinone substrates. In the case of 2,5-or 2,6-disubstituted quinones addition involving the substituted carbon takes place. Allylation with stereodefined allylboronates occurs with retention of the configuration.
Practical C-H functionalization of quinones with boronic acids
Fujiwara, Yuta,Domingo, Victoriano,Seiple, Ian B.,Gianatassio, Ryan,Del Bel, Matthew,Baran, Phil S.
supporting information; experimental part, p. 3292 - 3295 (2011/05/03)
A direct functionalization of a variety of quinones with several boronic acids has been developed. This scalable reaction proceeds readily at room temperature in an open flask using inexpensive reagents: catalytic silver(I) nitrate in the presence of a persulfate co-oxidant. The scope with respect to quinones is broad, with a variety of alkyl- and arylboronic acids undergoing efficient cross-coupling. The mechanism is presumed to proceed through a nucleophilic radical addition to the quinone with in situ reoxidation of the resulting dihydroquinone. This method has been applied to complex substrates, including a steroid derivative and a farnesyl natural product.
Total synthesis of polyprenylhydroquinols and benzoquinones
Bouzbouz, Samir,Kirschleger, Bernard,Villieras, Jean
, p. 67 - 84 (2007/10/03)
The total synthesis of polyprenylhydroquinols and benzoquinones is described.First, two appropriate aromatic allyl carbonates (moieties with one and two prenyls) and two activated bifunctional terpenyl derivatives (moieties with two and three prenyls) were synthesized.These molecules were then reacted together using a highly regio- and stereoselective coupling with Pd(PPh3)4 as a catalyst.The synthesis was achieved by functional group elimination and formation of quinonic and hydroquinonic moieties. - Keywords: polyprenylbenzoquinol; polyprenylhydroquinone; allylcarbonate; ?-allyl palladium complex
Isoprenoid derivatives and anti-ulcer agents containing the same
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, (2008/06/13)
Anti-ulcer agents containing isoprenoid derivatives are provided. The isoprenoid derivatives are represented by the formula: STR1 wherein: R represents a group of formula STR2 In the above formula, R1, R2 and R3 may be the
