71268-49-0Relevant academic research and scientific papers
Ylide-Functionalized Phosphine (YPhos)-Palladium Catalysts: Selective Monoarylation of Alkyl Ketones with Aryl Chlorides
Hu, Xiao-Qiang,Lichte, Dominik,Rodstein, Ilja,Weber, Philip,Seitz, Ann-Katrin,Scherpf, Thorsten,Gessner, Viktoria H.,Goo?en, Lukas J.
, p. 7558 - 7562 (2019)
Ylide-functionalized phosphine (YPhos) ligands allow the palladium-catalyzed α-arylation of alkyl ketones with aryl chlorides with record setting activity. Using a cyclohexyl-substituted YPhos ligand, a wide range of challenging ketone substrates was efficiently and selectively monoarylated under mild conditions. A newly designed YPhos ligand bearing tert-butyl groups on the coordinating phosphorus atom is already active at room temperature. The synthetic potential was demonstrated by gram-scale reactions and the succinct synthesis of ?-caprolactone derivatives.
