71273-36-4Relevant academic research and scientific papers
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold
Rodriguez, Alice L.,Zhou, Ya,Williams, Richard,David Weaver,Vinson, Paige N.,Dawson, Eric S.,Steckler, Thomas,Lavreysen, Hilde,MacKie, Claire,Bartolomé, José M.,MacDonald, Gregor J.,Scott Daniels,Niswender, Colleen M.,Jones, Carrie K.,Jeffrey Conn,Lindsley, Craig W.,Stauffer, Shaun R.
, p. 7388 - 7392 (2013/02/23)
Herein we report the discovery and SAR of a novel series of non-MPEP site metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs) based on an aryl glycine sulfonamide scaffold. This series represents a rare non-MPEP site
