71278-11-0

Basic information

• Product Name: 4-AMINO-1-PYRIDIN-3-YL-BUTAN-1-ONE
• Synonyms: 4-AMINO-1-PYRIDIN-3-YL-BUTAN-1-ONE;1-Butanone, 4-aMino-1-(3-pyridinyl)-
• CAS NO: 71278-11-0
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Mol File: 71278-11-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AMINO-1-PYRIDIN-3-YL-BUTAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-PYRIDIN-3-YL-BUTAN-1-ONE(71278-11-0)
• EPA Substance Registry System: 4-AMINO-1-PYRIDIN-3-YL-BUTAN-1-ONE(71278-11-0)

Safety Data

• Hazardous Substances Data: 71278-11-0(Hazardous Substances Data)

Upstream product

• 69963-21-9 4-Chloro-1-(3-pyridinyl)-1-butanone 
• 93-60-7 methyl 3-pyridinecarboxylate 

Relevant articles and documents

Method for synthesizing chiral nicotine from butyrolactone

The invention discloses a method for synthesizing chiral nicotine from butyrolactone. The fumarates and γ - butyrolactone are condensed under the action of a basic catalyst to yield 4 - chloro -1 - (3 - pyridine) -1 -butanone by reaction with hydrochloric acid and reacted with a chlorination reagent to produce (- B -) S (-4 -1 -dichlorobutyl) pyridine which is reacted with an amine reagent under basic conditions to give (-3 -) -1 -methyl nicotine and (S)-3 - nicotinic acetylbutanolamines obtained by the reaction with the aminating reagent under an alkaline condition to produce a chiral hydroxy S S group - (1) S- methylnicotine or a (4 -) S nicotinic acid. The application can determine whether a methylation reaction is needed according to the type of amination reagent. The yield of (S)- nicotine was high.