71281-30-6

Basic information

• Product Name: Benzenamine, 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-
• CAS NO: 71281-30-6
• Molecular Formula: C13H16F3N3O4
• Molecular Weight: 335.2790496
• Mol File: 71281-30-6.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenamine, 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-(71281-30-6)
• EPA Substance Registry System: Benzenamine, 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)-(71281-30-6)

Safety Data

• Hazardous Substances Data: 71281-30-6(Hazardous Substances Data)

Upstream product

• 393-75-9 4-chloro-3,5-dinitrobenzotrifluoride 
• 142-84-7 di-n-propylamine 
• 79816-19-6 C₁₈H₂₆F₃N₄O₄^(1-)*K⁽¹⁺⁾ 
• 79871-51-5 C₁₇H₂₆F₃N₄O₄^(1-)*K⁽¹⁺⁾ 
• 72283-22-8 C₁₃H₁₇F₃N₃O₅^(1-) 

Downstream Products

• 79816-19-6 C₁₈H₂₆F₃N₄O₄^(1-)*K⁽¹⁺⁾ 
• 16766-93-1 1-Dipropylamino-2,6-dinitro-4-tribrommethyl-benzol 
• 79871-51-5 C₁₇H₂₆F₃N₄O₄^(1-)*K⁽¹⁺⁾ 
• 72283-22-8 C₁₃H₁₇F₃N₃O₅^(1-) 

Relevant articles and documents

Trifluralin bulk drug synthesis method

The invention discloses a trifluralin bulk drug synthesis method, which comprises: carrying out a reaction by using p-chlorodinitrobenzotrifluoride and di-n-propylamine as raw materials, using causticsoda as a catalyst and using water as a reaction medium, and carrying out water washing, re-crystallization, centrifugation and vacuum drying to obtain trifluralin (2,6-dinitro-N,N-di-n-propyl-4-trifluoromethylaniline) finished product. Compared with the method in the prior art, the method of the invention has the following advantages that the used raw materials, catalysts and solvents are wide in source and convenient to prepare; caustic soda effectively promotes the reaction, the raw material conversion rate is high, the product selectivity is good, the synthesis reaction conversion rate ishigher than 99%, and the product purity is 99 wt%; the preparation process has low requirements on equipment, and special equipment does not need to be added; the discharge of three wastes in the reaction process is low, and the method is environment-friendly; and ethanol re-crystallization and convenient post-treatment are realized, so that the method is an environment-friendly trifluralin synthesis method and is beneficial to large-scale industrial development.

Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii

The synthesis and evaluation of 20 dinitroanilines and related compounds against the obligate intracellular parasite Toxoplasma gondii is reported. Using in vitro cultures of parasites in human fibroblasts, we determined that most of these compounds selectively disrupted Toxoplasma microtubules, and several displayed sub-micromolar potency against the parasite. The most potent compound was N1,N1-dipropyl-2,6-dinitro-4-(trifluoromethyl)-1,3- benzenediamine (18b), which displayed an IC50 value of 36 nM against intracellular T. gondii. Based on these data and another recent report [Ma, C.; Tran, J.; Gu, F.; Ochoa, R.; Li, C.; Sept, D.; Werbovetz, K.; Morrissette, N. Antimicrob. Agents Chemother. 2010, 54, 1453], an antimitotic structure-activity relationship for dinitroanilines versus Toxoplasma is presented.

Synergistic herbicidal compositions comprising 4-benzoylisoxazole and dinitroaniline herbicides

The invention relates to synergistic compositions comprising: (a) a 4-benzoylisoxazole of formula (I) STR1 wherein R, R1, R2 and n are as defined in the specification; and (b) a dinitroaniline herbicide; and to the use of these compounds as herbicides.