71309-86-9Relevant academic research and scientific papers
Heteroarylnitrones as drugs for neurodegenerative diseases: Synthesis, neuroprotective properties, and free radical scavenger properties
Porcal, Williams,Hernández, Paola,González, Mercedes,Ferreira, Ana,Olea-Azar, Claudio,Cerecetto, Hugo,Castro, Ana
body text, p. 6150 - 6159 (2009/10/23)
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative damage and the death induced by exposure to hydrogen peroxide. These heteroarylnitrones showed excellent peroxyl free radical absorbance capacities, analyzed by oxygen radical absorbance capacity (ORAC) assay with fluorescein as the fluorescent probe, ranging from 1.5- to 16.5-fold the value of the reference nitrone, α-phenyl-N-tert-butylnitrone (PBN). The electron spin resonance spectroscopy (ESR) demonstrated the ability of these derivatives to directly trap and stabilize oxygen, carbon, and sulfur-centered free radicals. These results demonstrated the potential use of these heteroarylnitrones as neuroprotective agents in preventing the death of cells exposed to enhanced oxidative stress and damage.
Nitrile Sulphides. Part 1. 1,3-Dipolar Cycloaddition to Carbonyl Groups activated by Trihaloalkyl Substituents; Synthesis and Crystal Structure of 1,3,4-Oxathiazoles
Damas, A. Margarida,Gould, Robert O.,Harding, Marjorie M.,Paton, R. Michael,Ross, John F.,Crosby, John
, p. 2991 - 2996 (2007/10/02)
Nitrile sulphides, generated by the thermal decarboxylation of 1,3,4-oxathiazol-2-ones, undergo 1,3-dipolar cycloaddition to the carbonyl group in chloral, hexachloroacetone and α,α,α-trifluoroacetophenone to yield 2,2,5-trisubstituted 1,3,4-oxathiazoles (18 - 76percent).Characterisation of the products is based on analytical and spectroscopic evidence, and is confirmed for 5-phenyl-2-trichloromethyl-1,3,4-oxathiazole and 5-(p-methoxyphenyl)-2-phenyl-2-trifluoromethyl-1,3,4-oxathiazole by X-ray crystal structure analyses.The oxathiazole rings are planar, with a localised C=N double bond.
