71319-67-0

Basic information

• Product Name: N-(2,6-dimethylphenyl)-1,2-diaminoethane
• Synonyms: N-(2,6-dimethylphenyl)-1,2-diaminoethane
• CAS NO: 71319-67-0
• Molecular Weight: 164.25
• Mol File: 71319-67-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2,6-dimethylphenyl)-1,2-diaminoethane(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-dimethylphenyl)-1,2-diaminoethane(71319-67-0)
• EPA Substance Registry System: N-(2,6-dimethylphenyl)-1,2-diaminoethane(71319-67-0)

Safety Data

• Hazardous Substances Data: 71319-67-0(Hazardous Substances Data)

Upstream product

• 2576-47-8 2-bromoethylamine hydrobromide 
• 87-62-7 2,6-dimethylaniline 
• 75889-19-9 N-(2-phthalimidoethyl)-2',6'-xylidine 

Downstream Products

• 86140-10-5 1-(indazol-4-yloxy)-3-[2-(2,6-dimethylphenylamino)-ethylamino]-propan-2-ol 
• 71314-17-5 1-Phenoxy-2-hydroxy-3-<2-(2,6-dimethylphenylamino)ethyl>aminopropanhydrochlorid 
• 76210-82-7 (4-{3-[2-(2,6-Dimethyl-phenylamino)-ethylamino]-2-hydroxy-propoxy}-phenyl)-urea 

Relevant articles and documents

C(sp3)-H alkenylation catalyzed by cationic alkylhafnium complexes: Stereoselective synthesis of trisubstituted alkenes from 2,6-dimethylpyridines and internal alkynes

Dibenzylhafnium complexes 3a-d, supported by dianionic bidentate or tridentate ligands, upon activation via abstraction by either [Ph3C][B(C6F5)4] or B(C6F5)3 served as catalysts for the C(sp3)-H alkenylation of 2,6-dimethylpyridines with dialkylalkynes to give corresponding C(sp3)-H alkenylated products 6. Complex 3c, containing a pyridine arm in the ligand skeleton, exhibited the highest catalytic activity among 3a-d; initial addition of 2,6-dimethylpyridine (4a) to the C6D5Br solution of 3c followed by [Ph3C][B(C6F5)4] and 3-hexyne (5a) produced trisubstituted alkene 6aa in stereoselective manner in up to 50% yield without any byproducts, while the addition of 5a prior to 4a and [Ph3C][B(C6F5)4] to the C6D5Br solution of 3c generated 6aa, together with the formation of byproduct (E)-(2-ethylpent-2-en-1-yl)benzene (7). When an asymmetrical pyridine, 3-bromo-2,6-dimethylpyridine, was used as the coupling partner, the corresponding trisubstituted alkene was obtained selectively. Catalytically active cationic benzylhafnium complexes 8a-d, which were prepared by the reactions of 3a-d and B(C6F5)3, respectively, were characterized by 1H, 13C, and 19F NMR spectroscopy. Kinetic studies of the catalytic reaction between 4a and 4-octyne (5b) using 3c and [Ph3C][B(C6F5)4] in C6D5Br revealed that the catalytic reaction was zero-order for both 4a and 5b, indicating that the rate-determining step involved the C(sp3)-H bond activation of 4a by vinylhafnium intermediate 11c.

POTENTIAL ANTIHYPERTENSIVE AGENTS. SOME GUANIDINE DERIVATIVES.

-