71360-06-0Relevant articles and documents
Cinchona alkali ligand and preparation method and application thereof
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Paragraph 0085-0087; 0089; 0093-0096; 0128-0129; 0134; ..., (2021/12/31)
The invention belongs to the field of organic chemical ligands, and particularly relates to a cinchona alkali ligand, which has a structure shown in a general formula I or a tautomer, an enantiomer and a diastereoisomer thereof, in the formula I, R1 is selected from alkyl, alkenyl and -CH = CHPh, R2 is selected from hydrogen, alkyl, phenyl and substituted phenyl, and R is selected from substituted phenyl. The invention also discloses a preparation method and application of the cinchona alkaloid ligand. The ligand disclosed by the invention has advantages in stereoselectivity and reaction efficiency, and a higher ee value and yield can be obtained in an asymmetric reaction.
METHODS FOR PREPARING BIS-TETRAHYDROISOQUINOLINE-CONTAINING COMPOUNDS
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Page/Page column 92; 93, (2019/02/06)
(-)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.
General and selective copper-catalyzed reduction of tertiary and secondary phosphine oxides: Convenient synthesis of phosphines
Li, Yuehui,Das, Shoubhik,Zhou, Shaolin,Junge, Kathrin,Beller, Matthias
scheme or table, p. 9727 - 9732 (2012/07/14)
Novel catalytic reductions of tertiary and secondary phosphine oxides to phosphines have been developed. Using tetramethyldisiloxane (TMDS) as a mild reducing agent in the presence of copper complexes, PO bonds are selectively reduced in the presence of other reducible functional groups (FGs) such as ketones, esters, and olefins. Based on this transformation, an efficient one pot reduction/phosphination domino sequence allows for the synthesis of a variety of functionalized aromatic and aliphatic phosphines in good yields.