7137-58-8Relevant academic research and scientific papers
Enantioselective Nitroso Aldol Reaction Catalyzed by a Chiral Phosphine–Silver Complex
Yanagisawa, Akira,Lin, Yuqin,Takeishi, Akihiro,Yoshida, Kazuhiro
, p. 5355 - 5359 (2016)
A catalytic asymmetric O-nitroso aldol reaction of alkenyl trifluoroacetates with nitrosoarenes was achieved by using QuinoxP*·AgOAc [(R,R)-QuinoxP* = (–)-(R,R)-2,3-bis(tert-butylmethylphosphino)quinoxaline] as the chiral precatalyst and N,N-diisopropylethylamine as the base precatalyst in the presence of methanol. Optically active α-aminooxy ketones with up to 99 % ee were regioselectively obtained in moderate to high yields by the in situ generated chiral silver enolates.
