71370-42-8

Basic information

• Product Name: [(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]ACETIC ACID
• Synonyms: CHEMBRDG-BB 4004244;AKOS BBS-00001875;[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]ACETIC ACID;[(1-METHYL-1H-IMIDAZOL-2-YL)THIO]ACETIC ACID;AKOS AKM00133;UKRORGSYN-BB BBV-037330;[(1-methyl-1H-imidazol-2-yl)thio]acetic acid(SALTDATA: FREE);2-(1-Methyl-1H-imidazol-2-ylthio)acetic acid
• CAS NO: 71370-42-8
• Molecular Formula: C6H8N2O2S
• Molecular Weight: 172.2
• Mol File: 71370-42-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 382.2°C at 760 mmHg
• Flash Point: 185°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 1.59E-06mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: [(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]ACETIC ACID(71370-42-8)
• EPA Substance Registry System: [(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]ACETIC ACID(71370-42-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 71370-42-8(Hazardous Substances Data)

Usage

General Description

[(1-Methyl-1H-imidazol-2-yl)sulfanyl]acetic acid, also known as MIAA, is a chemical compound with the molecular formula C6H8N2O2S. It is derived from imidazole and is used in the synthesis of certain pharmaceuticals and organic compounds. MIAA has potential therapeutic uses as an anti-inflammatory and anti-ulcer agent due to its ability to inhibit the production of prostaglandins. It is also used as a building block in organic synthesis, particularly in the creation of heterocyclic compounds. MIAA is a white crystalline solid that is soluble in water and other organic solvents, and its chemical structure makes it a valuable starting material for the production of various pharmaceuticals and biologically active compounds.

InChI:InChI=1/C6H8N2O2S/c1-8-3-2-7-6(8)11-4-5(9)10/h2-3H,4H2,1H3,(H,9,10)

Upstream product

• 164979-73-1 [(1-methyl-2-imidazolyl)thio]acetic acid ethyl ester 
• 79-08-3 bromoacetic acid 
• 60-56-0 2-Mercapto-1-methylimidazole 
• 60-56-0 1-methyl-1,3-dihydro-imidazole-2-thione 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

Development of a biomimetic enzyme-linked immunosorbent assay method for the determination of methimazole in urine sample

A fast and direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method was developed for the determination of methimazole (MMZ) in urine sample based on a molecularly imprinted film as an artificial antibody. This is the first example to monitor methimazole with a direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method. The imprinted film was directly synthesized on the well surface of MaxiSorp polystyrene 96-well plate and characterized. The results showed that it exhibited an antibody-like binding ability, rapid adsorption speed, high stability, which was particularly advantageous and suitable for BELISA development. The BELISA method established in this paper had a higher selectivity for MMZ than for the structurally related compounds and the IC50 (calculated as the concentration giving 50% inhibition of color development) and the detection limit values under optimized experimental conditions were 70 ± 4 μg L-1 and 0.9 ± 0.04 μg L-1, respectively. The method was applied to the determination of MMZ in spiked urine sample with excellent recoveries ranging from 90% to 95%, and the imprinted film was able to be reused for 20 times without loss of sensitivity. The results obtained by BELISA correlated well with that obtained by the high performance liquid chromatography (HPLC) method.