714-23-8Relevant academic research and scientific papers
Homobenzylic Oxygenation Enabled by Dual Organic Photoredox and Cobalt Catalysis
McManus, Joshua B.,Griffin, Jeremy D.,White, Alexander R.,Nicewicz, David A.
supporting information, p. 10325 - 10330 (2020/07/27)
Activation of aliphatic C(sp3)-H bonds in the presence of more activated benzylic C(sp3)-H bonds is often a nontrivial, if not impossible task. Herein we show that leveraging the reactivity of benzylic C(sp3)-H bonds to achieve reactivity at the homobenzylic position can be accomplished using dual organic photoredox/cobalt catalysis. Through a two-part catalytic system, alkyl arenes undergo dehydrogenation followed by an anti-Markovnikov Wacker-type oxidation to grant benzyl ketone products. This formal homobenzylic oxidation is accomplished with high atom economy without the use of directing groups, achieving valuable reactivity that traditionally would require multiple chemical transformations.
Preparation method for synthesis of phenolic ester through thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction
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Paragraph 0079; 0080; 0097; 0098; 0099, (2018/07/30)
The invention discloses a preparation method for synthesis of phenolic ester through a thiocarboxylic acid mediated visible light catalyzed phenol acylation reaction. Thiocarboxylic acid compounds andphenol compounds are subjected to a site specific reaction under certain conditions to produce phenolic ester compounds, wherein the certain conditions are as follows: under the conditions of normaltemperature, normal pressure and visible light, K2CO3 is used as an alkaline catalyst, terpyridyl ruthenium dichloride hexahydrate is used as a photosensitizer and acetonitrile is used as a reaction solvent. Synthesis of phenolic ester under catalysis of visible light is realized, thiocarboxylic acid is used as an acylation reagent, and the site specific phenol esterification reaction is realizedefficiently under mild conditions of normal temperature, normal pressure and visible light. The method has mild reaction conditions, large substrate functional group tolerance, high applicability andhigh yield, and an efficient, reliable and economical preparation method is provided for synthesis of phenolic ester.
Magnesium-promoted reductive silylation and acylation of tropone and tropone acetal
Maekawa, Hirofumi,Nagakubo, Keisuke,Nishi, Midori,Nishimura, Makoto,Nagahara, Daisuke
, p. 1183 - 1189 (2013/11/19)
Magnesium-promoted reductive coupling of chlorotrialkylsilanes and tropone or tropone acetal in DMF, followed by oxidation with 2,3-dichloro-5,6-dicyano-1, 4-benzoquinone in benzene gives 2-trialkylsilyltropones as the main product, and the reductive coup
A Novel Route to Arylacetones via a Masked α-Acylcarbonium Intermediate
Shatzmiller, Shimon,Lidor, Ramy,Shalom, Eytan,Bahar, Eliezer
, p. 795 - 796 (2007/10/02)
The Ag+ induced aromatic substitution reaction of bromoacetone O-methyloxime is described.
