714-32-9

Basic information

• Product Name: (Z)-3-(4-methoxyphenylthio)acrylic acid
• Synonyms: (Z)-3-(4-methoxyphenylthio)acrylic acid
• CAS NO: 714-32-9
• Molecular Weight: 210.254
• Mol File: 714-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-3-(4-methoxyphenylthio)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(4-methoxyphenylthio)acrylic acid(714-32-9)
• EPA Substance Registry System: (Z)-3-(4-methoxyphenylthio)acrylic acid(714-32-9)

Safety Data

• Hazardous Substances Data: 714-32-9(Hazardous Substances Data)

Upstream product

• 696-63-9 4-Methoxybenzenethiol 
• 471-25-0 Propiolic acid 
• 696-62-8 para-iodoanisole 

Downstream Products

• 108127-50-0 ethynyl(4-methoxyphenyl)sulfane 

Relevant articles and documents

Palladium-Catalyzed Synthesis of (Z)-3-Arylthioacrylic Acids and Thiochromenones

The three-component reaction of aryl halides, sodium sulfide pentahydrate (Na2S×5 H2O), and propiolic acid in the presence of 2.5% bis(triphenylphosphine)palladium chloride [Pd(PPh3) 2Cl2], 5% 1,4-bis(diphenylphosphino)butane (dppb) and 2equivalents of 1,8-diazabicycloundec-7-ene (DBU) produces stereoselectively (Z)-3-arylthioacrylic acids in good yields. A study of the reaction pathway suggested that the C-S bond formation between aryl halides and Na 2S×5 H2O proceeded first, and the resulting intermediate reacted with propiolic acid to produce the desired product. In addition, when the resulting product was treated with acid, the respective thiochromenones were formed in good yields. Copyright