714-88-5Relevant academic research and scientific papers
Synthesis, surface-active properties, and anthelmintic activities of new cationic gemini surfactants against the gastrointestinal nematode, heligmosomoides polygyrus bakeri, in vitro
Sanchez, Victoria G.,Giudici, Claudio J.,Bassi, Amilcar R.,Murguia, Marcelo C.
, p. 463 - 470 (2012)
A novel series of cationic dimeric surfactants was prepared involving the ketalization reaction, Williamson etherification, and regioselective oxirane ring opening with tertiary alkyl amines. The synthesized compounds were obtained in high purity by a simple purification procedure using column chromatography. The critical micelle concentration (CMC), effectiveness of surface tension reduction (γCMC), surface excess concentration (λ), and area per molecule at the interface (A) were determined and values indicate that the cationic series is characterized by good surface-active and self-aggregation properties. For the first time, we reported the anthelmintic activities against the rodent gastrointestinal nematode Heligmosomoides polygyrus bakeri, in vitro for cationic gemini compounds. In the series of five tested cationic compounds (4a-e), three of them (4a, 4b and 4d) were shown to have an excellent anthelmintic activity in vitro at different concentrations. The anthelmintic activity was found to be dependent on the type of cationic compound, concentration and incubation time. The cationic di-C12 (4a) derivate of the series was the best anthelmintic agent, its use was optimal at a minimum concentration of 50 ppm and with 60 min of incubation. AOCS 2012.
SALT, RESIST COMPOSITION, AND METHOD FOR PRODUCING RESIST PATTERN
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Paragraph 0240, (2019/10/01)
PROBLEM TO BE SOLVED: To provide a salt capable of producing a resist pattern with good CD uniformity. SOLUTION: The salt is represented by formula (I) [Q1, Q2, Q1' and Q2' each represent F or the like; R1, R2, R1' and R2' each represent H, F, or the like; z and z' each represent an integer of 0-6; X1 and X1' each represent *-CO-O- or the like; L1 represents a substituted/unsubstituted hydrocarbon group; R3 and R4 each represent H, a group represented by formula (1a) or formula (2a), or the like; Raa1, Raa2 and Raa3 each represent an alkyl group; naa represents 0 or 1; Raa1' and Raa2' each represent H or the like; Raa3' represents an alkyl group; Xc represents O or S; and Z+ and Z'+ each represent an organic cation]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
METHOD FOR MANUFACTURING (METH)ACRYLOYL GROUP-CONTAINING POLYOL COMPOUND, (METH)ACRYLOYL GROUP-CONTAINING POLYOL COMPOUND, AND URETHANE (METH)ACRYLATE
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Paragraph 0091-0093, (2017/01/02)
To provide a simple, efficient method for manufacturing a (meth)acryloyl group-containing polyol compound, a (meth)acryloyl group-containing polyol compound produced by the manufacturing method, and an urethane (meth)acrylate produced by using the compound.A method for manufacturing a (meth)acryloyl group-containing polyol compound (x3) includes the steps of producing a hydroxyl group-containing ketal compound (x1) by reacting a polyol compound (A) having at least three hydroxyl groups in the molecular structure with a cyclic ketone compound (B) at the proportion in which the ratio [(OH)/(CO)] of the number of moles of hydroxyl groups (OH) included in the polyol compound (A) to the number of moles of carbonyl groups (CO) included in the cyclic ketone compound (B) falls within the range of 3 to 12 in an organic solvent (S) in the presence of an acid catalyst, producing a (meth)acrylate compound (x2) by (meth)acrylating hydroxyl groups included in the resulting hydroxyl group-containing ketal compound (x1), and hydrolyzing the resulting (meth)acrylate compound (x2).
METHOD FOR MANUFACTURING (METH)ACRYLOYL GROUP-CONTAINING POLYOL COMPOUND, (METH)ACRYLOYL GROUP-CONTAINING POLYOL COMPOUND, AND URETHANE (METH)ACRYLATE
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Paragraph 0058-0059, (2015/01/16)
To provide a simple, efficient method for manufacturing a (meth)acryloyl group-containing polyol compound, a (meth)acryloyl group-containing polyol compound produced by the manufacturing method, and an urethane (meth)acrylate produced by using the compound.A method for manufacturing a (meth)acryloyl group-containing polyol compound (x3) includes the steps of producing a hydroxyl group-containing ketal compound (x1) by reacting a polyol compound (A) having at least three hydroxyl groups in the molecular structure with a cyclic ketone compound (B) at the proportion in which the ratio [(OH)/(CO)] of the number of moles of hydroxyl groups (OH) included in the polyol compound (A) to the number of moles of carbonyl groups (CO) included in the cyclic ketone compound (B) falls within the range of 3 to 12 in an organic solvent (S) in the presence of an acid catalyst, producing a (meth)acrylate compound (x2) by (meth)acrylating hydroxyl groups included in the resulting hydroxyl group-containing ketal compound (x1), and hydrolyzing the resulting (meth)acrylate compound (x2).
Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry
Burke, Anthony M.,Kandur, Wynne,Novitsky, Eric J.,Kaake, Robyn M.,Yu, Clinton,Kao, Athit,Vellucci, Danielle,Huang, Lan,Rychnovsky, Scott D.
, p. 5030 - 5037 (2015/05/05)
The cross-linking Mass Spectrometry (XL-MS) technique extracts structural information from protein complexes without requiring highly purified samples, crystallinity, or large amounts of material. However, there are challenges to applying the technique to protein complexes in vitro, and those challenges become more daunting with in vivo experiments. Issues include effective detection and identification of cross-linked peptides from complex mixtures. While MS-cleavable cross-linkers facilitate the sequencing and identification of cross-linked peptides, enrichable cross-linkers increase their detectability by allowing their separation from non-cross-linked peptides prior to MS analysis. Although a number of cross-linkers with single functionality have been developed in recent years, an ideal reagent would incorporate both capabilities for XL-MS studies. Therefore, two new cross-linkers have been designed and prepared that incorporate an azide (azide-A-DSBSO) or alkyne (alkyne-A-DSBSO) to enable affinity purification strategies based on click chemistry. The integration of an acid cleavage site next to the enrichment handle allows easy recovery of cross-linked products during affinity purification. In addition, these sulfoxide containing cross-linking reagents possess robust MS-cleavable bonds to facilitate fast and easy identification of cross-linked peptides using MS analysis. Optimized, gram-scale syntheses of these cross-linkers have been developed and the azide-A-DSBSO cross-linker has been evaluated with peptides and proteins to demonstrate its utility in XL-MS analysis.
A Facile, Selective Preparation of Monoketals from Pentaerythritol and Ketones
Murguia, Marcelo C.,Vaillard, Santiago E.,Grau, Ricardo J.
, p. 1093 - 1097 (2007/10/03)
The selective preparation of monoketals 3a-f from pentaerythritol 1 and cyclic, acyclic, aromatic, and aliphatic ketones 2a-f was achieved by a facile method. The extreme polarity and low solubility of pentaerythritol in almost all organic solvents were the main difficulties to be overcome for the preparation of monoketals in good yields and high selectivity. A benzene-dimethylformamide (40:60) mixture proved to be excellent for the ketalization. The one-step procedure developed allowed the preparation of monoketals in good yields and good to excellent selectivity (higher than 90 percent).
Synthesis of new pentaerythritol-based gemini surfactants
Murguía,Grau
, p. 1229 - 1232 (2007/10/03)
New dimeric or gemini surfactants bearing double-chain with two or four sulfonate groups, and quadruple-chain with four sulfonate groups, were prepared from pentaerythritol in good overall yields. All these surfactants showed excellent surface-active prop
