71413-04-2

Basic information

• Product Name: (2RS)-1-benzoylpiperidine-2-carbonitrile
• Synonyms: (2RS)-1-benzoylpiperidine-2-carbonitrile
• CAS NO: 71413-04-2
• Molecular Weight: 214.267
• Mol File: 71413-04-2.mol

Chemical Properties

• CAS DataBase Reference: (2RS)-1-benzoylpiperidine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS)-1-benzoylpiperidine-2-carbonitrile(71413-04-2)
• EPA Substance Registry System: (2RS)-1-benzoylpiperidine-2-carbonitrile(71413-04-2)

Safety Data

• Hazardous Substances Data: 71413-04-2(Hazardous Substances Data)

Upstream product

• 78348-46-6 N-benzoyl-2-piperidinecarboxylic acid 
• 50838-24-9 (3,4-dihydropyridin-1(2H)-yl)(phenyl)methanone 
• 19158-51-1 P-toluenesulfonyl cyanide 

Downstream Products

• 171800-73-0 1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile 
• 1208110-10-4 (2RS)-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208110-65-9 6-methoxy-1'-(2-oxo-2-phenylethyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one 
• 1208110-16-0 6-methoxy-1'-(2-phenylpropyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208109-86-7 6-methoxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208110-13-7 (2RS)-7-methoxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208109-85-6 1'-[2-(4-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208110-63-7 1'-[2-(4-fluoro-2-methylphenyl)ethyl]-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208110-26-2 (2RS)-6-hydroxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one 
• 1208110-40-0 (2RS)-N-{1'-[2-(2-methylphenyl)ethyl]-1-oxo-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-6-yl}acetamide 
• 1208110-41-1 (2RS)-1'-[2-(2-methylphenyl)ethyl]-6-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208109-94-7 (2R)-6-methoxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208110-27-3 C₂₄H₂₆F₃NO₄S 
• 1208109-99-2 (2S)-1'-[2-(4-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 

Relevant articles and documents

Cobalt-catalyzed hydrocyanation and hydroarylation of enamines

A mild, general and efficient hydrocyanation and hydroarylation of enamines catalyzed by Co(salen) complexes are described. Both reactions include regioselective C[sbnd]H bond formation of enamines, and the corresponding products are obtained in high yield. Hydroarylation critically discriminates the benzyl and benzoyl aromatic rings on nitrogen in cyclization step, and the corresponding isoindolinones including quaternary carbons are exclusively given.

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.