71422-88-3Relevant academic research and scientific papers
Synthesis and biological evaluation of norcantharidin derivatives as protein phosphatase-1 inhibitors
Zhao, Jie,Guan, Xiao-Wen,Chen, Shi-Wu,Hui, Ling
, p. 363 - 366 (2015)
Cantharidin and norcantharidin display anticancer activity against a broad range of tumor cell lines. In this study, we have synthesized a series of norcantharidin derivatives and evaluated their cytotoxic effects on four human tumor cell lines together with the genetically normal human diploid fibroblast line WI-38. One of our compounds (1S,4R)-3-((4-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl) phenyl)carbamoyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid (12) exhibited potent cytotoxic effects on the tumor cell lines A-549, HepG2, HeLa, and HCT-8, whereas it was less toxic to WI-38 cells than its parent compound, norcantharidin. In addition, this compound inhibited protein phosphatase-1 activity and microtubule formation in HeLa cells, and it also interacts with calf thymus DNA.
Antihypertensive 4-aminoquinolines
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, (2008/06/13)
Antihypertensive compounds for the treatment of hypertensive mammals, including man, of the formula III: STR1 wherein X is chloro or trifluoromethyl; wherein R is a radical such as triazinyl, pyrazinyl, pyridinyl, pyrimidinyl, phenyl, or the above radical
