714253-25-5

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 141-97-9 ethyl acetoacetate 
• 109-77-3 malononitrile 
• 302-01-2 hydrazine 
• 105-45-3 acetoacetic acid methyl ester 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Relevant academic research and scientific papers

Green synthesis of tetrahydrobenzo[b] pyrans, pyrano[2,3-c] pyrazoles and spiro[indoline-3,4′-pyrano[2,3-c] pyrazoles catalyzed by nano-structured diphosphate in water

A green and recoverable nano-structured diphosphate (Na2CaP2O7) was synthesized and fully characterized using FT-IR spectra, X-ray diffraction patterns (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray

Preparation of GO/SiO2/PEA as a new solid base catalyst for the green synthesis of some spirooxindole derivatives

Efficient and green one pot multi component synthesis of some spirooxindole derivatives in the presence of graphene oxide functionalized with 2-(1-piperazinyl) ethylamine (GO/SiO2/PEA) as a solid base catalyst was studied. GO/SiO2/PEA has been obtained through a two step reaction and characterized by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), thermo gravimetric analysis (TGA), Raman spectroscopy and X-ray diffraction (XRD). Green reaction conditions, short reaction times, reusable catalyst and a high to excellent yield of products are some of the advantageous of the presented method.

Synthesis of functionalized chromene and spirochromenes using L-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature

An efficient and recyclable homogeneous catalyst is developed using commercially cheap L-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, L-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity.

ZrO2 nanoparticles as a reusable solid dual acid-base catalyst for facile one-pot synthesis of multi-functionalized spirooxindole derivatives under solvent free condition

A two-step one-pot protocol for the facile synthesis of biologically important spirooxindole derivatives such as spiro[4H-pyran-3,3′-oxindoles] and spiro[indoline-3,4′(1H′)-pyrano-[2,3-c]pyrazol-2-ones has been developed. In this method ZrO2 na

Green access to multi-component synthesis of spiropyranopyrazoles

A catalyst-free multi-component synthesis of spiro[indoline-3,4'-pyrano[2, 3-c]pyrazoles] is reported from in situ formed pyrazolone by exothermic reaction of ethyl acetoacetate with hydrazine hydrate, isatin and malononitrile in water at room temperature. A suggested mechanistic approach was supported by semi-empirical calculations. The transformation is carried out in water alone and thus achieved the highest level of green chemistry. Simple reaction conditions, easy work-up procedure and isolation of products are the auxiliary advantages of present protocol.

Chitosan/ionic liquid forms a renewable and reusable catalyst system used for the synthesis of highly functionalized spiro derivatives

Chitosan, a reusable heterogeneous catalyst, can be combined with an ionic liquid as a green solvent to generate a highly efficient catalyst system for our densely functionalised and diversified target molecule. The reaction is completed with a good to ex

Novel and efficient one-pot synthesis of spiro[indoline-3,4'-pyrano [2,3-c]pyrazole]derivatives catalysed by L-proline in aqueous medium

An efficient mild one-pot synthesis of spiro[indoline-3,4'-pyrano[2,3-c] pyrazole derivatives by a four-component reaction of hydrazine, a β-keto ester, isatin, and malononitrile catalysed by L-proline in water is reported.

Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives

Meglumine, a bio-based chemical, was demonstrated to be a highly efficient and reusable catalyst for the synthesis of a series of pyranopyrazole derivatives via a one-pot, four-component reaction of carbonyl compound or isatin, hydrazine hydrate, malononi

Rapid and efficient ultrasound-assisted method for the combinatorial synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives

An efficient one-pot synthesis of spiro[indoline-3,4′-pyrano[2,3-c] pyrazole] derivatives by four-component reaction of hydrazine, β-keto ester, isatin, and malononitrile or ethyl cyanoacetate catalyzed by piperidine under ultrasound irradiation is descri